FlyBase Allele Report: Dmel\cas[24]

General Information

Symbol

Dmel\cas²⁴

Species

D. melanogaster

Name

FlyBase ID

FBal0032145

Feature type

allele

Associated gene

Dmel\cas

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

amorphic allele - genetic evidence

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Cui and Doe, 1992)

Mutagen

Delta2-3 transposase

(Cui and Doe, 1992)

Progenitor genotype

cas²⁰⁹²

(Cui and Doe, 1992)

Cytology

Description

Lacks 850bp of genomic DNA flanking P element insertion of cas²⁰⁹².

(Cui and Doe, 1992)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

increased cell number | embryonic stage

(Fox et al., 2022)

increased occurrence of cell division | larval stage

(Sood et al., 2022)

lethal - all die during embryonic stage | recessive

(Cui and Doe, 1992)

some die during embryonic stage | recessive

(Cui and Doe, 1992)

Phenotype Manifest In

larval central brain

(Sood et al., 2022)

larval posterior commissure

(Cui and Doe, 1992)

neuroblast

(Maurange et al., 2008)

U neuron | embryonic stage | increased number

(Fox et al., 2022)

Detailed Description

Statement

Reference

In cas²⁴ homozygotes, the larval central brain exhibits ectopically proliferating neuroblasts (i.e. increased numbers in S-phase), compared to controls.

(Sood et al., 2022)

Entry into quiescence is delayed in cas²⁴ mutant NB3-3T neuroblasts.

(Lai and Doe, 2014)

Neuroblasts in abdominal cas²⁴ clones induced during early embryogenesis fail to undergo apoptosis at 96 hours.

(Maurange et al., 2008)

Posterior commissure has only half the diameter of wild type embryos: one fasciclin III- positive fascicle is missing.

(Cui and Doe, 1992)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

cas²⁴ has increased cell number | embryonic stage phenotype, non-enhanceable by Cph¹

(Fox et al., 2022)

NOT suppressed by

Statement

Reference

cas²⁴ has increased cell number | embryonic stage phenotype, non-suppressible by Cph¹

(Fox et al., 2022)

cas²⁴ has increased cell number | embryonic stage phenotype, non-suppressible by Scer\GAL4^en-e16E/Cph^UAS.RL

(Fox et al., 2022)

NOT Enhancer of

Statement

Reference

cas²⁴ is a non-enhancer of increased cell number | embryonic stage phenotype of Cph¹

(Fox et al., 2022)

NOT Suppressor of

Statement

Reference

cas²⁴ is a non-suppressor of increased cell number | embryonic stage phenotype of Cph¹

(Fox et al., 2022)

Other

Statement

Reference

Kr^UAS.cHa, Scer\GAL4^en-e16E, cas²⁴ has abnormal cell number | embryonic stage phenotype

(Fox et al., 2022)

Phenotype Manifest In

NOT Enhanced by

Statement

Reference

cas²⁴ has U neuron | embryonic stage | increased number phenotype, non-enhanceable by Cph¹

(Fox et al., 2022)

NOT suppressed by

Statement

Reference

cas²⁴ has U neuron | increased number | embryonic stage phenotype, non-suppressible by Cph¹

(Fox et al., 2022)

cas²⁴ has U neuron | increased number | embryonic stage phenotype, non-suppressible by Scer\GAL4^en-e16E/Cph^UAS.RL

(Fox et al., 2022)

NOT Enhancer of

Statement

Reference

cas²⁴ is a non-enhancer of U neuron | embryonic stage | increased number phenotype of Cph¹

(Fox et al., 2022)

NOT Suppressor of

Statement

Reference

cas²⁴ is a non-suppressor of U neuron | increased number | embryonic stage phenotype of Cph¹

(Fox et al., 2022)

Other

Statement

Reference

Kr^UAS.cHa, Scer\GAL4^en-e16E, cas²⁴ has U neuron | embryonic stage phenotype

(Fox et al., 2022)

Additional Comments

Genetic Interactions

Statement

Reference

Df(2L)ED773 ; cas²⁴ double mutant embryos lack the extra U4 neurons found in cas^- single mutants, without affecting the U1-U3 neuron fates.

(Grosskortenhaus et al., 2006)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

en expression in the CNS is abnormal.

(Cui and Doe, 1992)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Cas²⁴

(Sood et al., 2022)

cas²⁴

(An et al., 2023, Fox et al., 2022, Ren et al., 2017, Syed et al., 2017, Walsh and Doe, 2017, Lacin and Truman, 2016, Narbonne-Reveau et al., 2016, Zacharioudaki et al., 2016, Lai and Doe, 2014, Chai et al., 2013, Fontana and Crews, 2012, Kao et al., 2012, Hwang and Rulifson, 2011, Maurange et al., 2008, Grosskortenhaus et al., 2006)

ming²⁴

(Cui and Doe, 1992)

Name Synonyms

Secondary FlyBase IDs

References (17)

Report Sections

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