FB2024_03 , released June 25, 2024
Allele: Dmel\crbS87-9
Open Close
General Information
Symbol
Dmel\crbS87-9
Species
D. melanogaster
Name
FlyBase ID
FBal0030959
Feature type
allele
Associated gene
Dmel\crb
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Tepass and Knust, 1993, Tepass and Knust, 1990)
Mutagen
X ray
(Tepass and Knust, 1990)
Progenitor genotype
Cytology

Polytene chromosomes normal.

(Tepass and Knust, 1990)
Description

Point mutation.

(Tepass and Knust, 1990)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Strong phenotype. Embryos almost completely lack cuticle: due to cell death in epidermal primordium. Morphogenetic abnormalities in the developing tracheal system result in few remaining aggregates of tracheal cells. Morphogenetic abnormalities and cell death were detected in the presumptive foregut and hindgut. Salivary glands also undergo cell death.

      (Tepass and Knust, 1990)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Strong crb allele.

      (Tepass and Knust, 1990)

      The phenotype of amorphic crb mutants is essentially the same as the phenotype of amorphic sdt mutants. Embryos doubly mutant for sdt and crb mutants show the same phenotype as embryos singly mutant for either gene. Phenotype can be alleviated by a duplication for sdt+, Dp(1;2)sn+72d.

      (Tepass and Knust, 1993)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      crbS87-9
      Name Synonyms
      Secondary FlyBase IDs
        References (2)