FB2024_03 , released June 25, 2024
Allele: Dmel\crbD88-3
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General Information
Symbol
Dmel\crbD88-3
Species
D. melanogaster
Name
FlyBase ID
FBal0030952
Feature type
allele
Associated gene
Dmel\crb
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Tepass and Knust, 1993)
Mutagen
X ray
(Tepass and Knust, 1990)
Progenitor genotype
Cytology

Polytene chromosomes normal.

(Tepass and Knust, 1990)
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference

      In contrast to most ot the crb mutants tested, a positive signal is detected with the crb antibody in crbD88-3 mutant embryos.

      (Tepass et al., 1990)
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  Leber congenital amaurosis
      CEA
      (Izaddoost et al., 2002)
      model of  retinitis pigmentosa
      CEA
      (Izaddoost et al., 2002)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      crbD88-3 mutants form shorter spiracles and show general defects in epithelial organization.

      (Lovegrove et al., 2006)

      Clones in the eye show lack of rhabdomere elongation. The rhabdomeres remain at the top of the retina and appear thicker than wild-type rhabdomeres. Adherens junctions stretch further basolaterally than in wild type. Those at the distal portion of the retina are variable in size and those that are proximal are discontinuous and thin. The adherens junctions attaching the photoreceptors to the floor of the retina remain relatively intact.

      (Izaddoost et al., 2002)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      crbD88-3
      (Lovegrove et al., 2006)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)