FB2024_03 , released June 25, 2024
Allele: Dmel\eyaE7
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General Information
Symbol
Dmel\eyaE7
Species
D. melanogaster
Name
FlyBase ID
FBal0030772
Feature type
allele
Associated gene
Dmel\eya
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Bui et al., 2000, Bonini et al., 1998, Bonini et al., 1993)
Progenitor genotype
Cytology
Description

Nucleotide substitution: C2323T. Amino acid replacement: T643I.

(Bui et al., 2000)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:6,528,441..6,528,441 [-]
Nucleotide change:

C6528441T

Reported nucleotide change:

C2323T

Amino acid change:

T649I | eya-PA; T643I | eya-PB; T559I | eya-PC

Reported amino acid change:

T643I

(Bui et al., 2000)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      eya1/eyaE7 flies have eyes 1/4 to less than 1/2 normal size. More than 50% of eyaE7/eyaE(P)10 animals die as embryos.

      (Bui et al., 2000)

      eyaE7/eya1 flies have eyes that are between 1/4 and less than 1/2 normal size. eyaE7/eya3 flies have eyes that are less than 1/4 normal size.

      (Bonini et al., 1998)

      Less than 50% of eyaE7/Df(2L)eya10 embryos hatch. Less than 50% of eyaE7/eyaE3 animals survive to adulthood. Adults have eyes which are less than 1/2 normal size. eyaE7/eya4 flies have eyes which are less than 1/2 normal size.

      (Leiserson et al., 1998)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially complements

      eya1

      (Bonini et al., 1993)
      Comments

      Fails to complement eye phenotype of eya1.

      (Bonini et al., 1993)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      clieya-E7
      eyaE7
      Name Synonyms
      Secondary FlyBase IDs
        References (4)