FlyBase Allele Report: Dmel\cact[BQ]

General Information

Symbol

Dmel\cact^BQ

Species

D. melanogaster

Name

FlyBase ID

FBal0030692

Feature type

allele

Associated gene

Dmel\cact

Associated Insertion(s)

P{}cact^BQ

Carried in Construct

Also Known As

P{}cact^BQ

Key Links

Genomic Maps

JBrowse

Allele class

gain of function allele

Mutagen

PM hybrid dysgenesis

Nature of the Allele

Allele class

gain of function allele

(Bergmann et al., 1996, Geisler et al., 1995, Govind et al., 1993, Whalen and Steward, 1993)

Mutagen

PM hybrid dysgenesis

(Ashburner et al., 1999.10.12, Roth et al., 1991)

Progenitor genotype

Associated Insertion(s)

P{}cact^BQ

Cytology

Description

P-element insertion into the coding sequence of the second exon. An upstream portion of the second exon is spliced out upstream of codon 44. The ATG at position 145 is the first possible initiator resulting in an N-terminally truncated protein lacking the first 144 amino acids.

(Bergmann et al., 1996)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2L:16,324,333..16,325,054

(Bergmann et al., 1996, Roth et al., 1991)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible

(Roth et al., 1991)

Phenotype Manifest In

embryonic/first instar larval cuticle | ventral

(Bergmann et al., 1996)

embryonic ventral epidermis

(Govind et al., 1993)

Detailed Description

Statement

Reference

No cact³/cact^BQ; Tl³/+ adults or cact³/cact^BQ ; Tl⁸/+ adults have melanotic capsules.

(Qiu et al., 1998)

Causes a dorsalised phenotype.

(Bergmann et al., 1996)

Females homozygous for this allele or heterozygous for this allele and a deficiency for cact generate strongly dorsalized or dorsolateralized embryos. Females transheterozygous for this allele and a loss of function allele result in embryos in which ventral structures are progressively lost at the expense of dorsal structures as the strength of the loss of function allele increases.

(Govind et al., 1993)

When in trans to loss-of-function cact alleles a dorsalized embryo is generated.

(Roth et al., 1991)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement