FlyBase Allele Report: Dmel\Rh3[Rh1+3]

General Information

Symbol

Dmel\Rh3^Rh1+3

Species

D. melanogaster

Name

FlyBase ID

FBal0030113

Feature type

allele

Associated gene

Dmel\Rh3

Associated Insertion(s)

Carried in Construct

P{Rh3^Rh1+3}

Key Links

Transgenic product class

wild_type

(Feiler et al., 1992)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Feiler et al., 1992)

Mutagen

in vitro construct

(Shetty et al., 1998, Feiler et al., 1992)

Progenitor genotype

Carried in construct

P{Rh3^Rh1+3}

Cytology

Description

Construct: Entire gene and upstream sequences of Rh3 are fused to 2.8kb ninaE promoter fragment containing 67 nucleotides of untranslated leader sequence.

(Feiler et al., 1992)

Allele components

Component

Use(s)

Regulatory region(s)

ninaE

Encoded product / tool

Rh3

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neurophysiology

(Liu et al., 2008)

Phenotype Manifest In

ommatidium

(Liu et al., 2008)

Detailed Description

Statement

Reference

Whole-cell voltage-clamp recordings of dissociated ommatidia from flies of the genotype ninaE¹⁷,Rh3^Rh1+3 (in which the UV responsive Rh3 is driven in place of ninaE by this latter's promoter) show similar, albeit slightly slower, kinetics to responses from wildtype ommatidia. Quantum bumps are similar in waveform, but slightly larger than wildtype, and a similar dependence on Ca[2+] is seen.

(Liu et al., 2008)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Rh3^Rh1+3 has abnormal neurophysiology phenotype, suppressible by ninaC⁵

(Liu et al., 2008)

NOT suppressed by

Statement

Reference

Rh3^Rh1+3 has abnormal neurophysiology phenotype, non-suppressible by ninaE¹⁷

(Liu et al., 2008)

Suppressor of

Statement

Reference

Rh3^Rh1+3 is a suppressor of abnormal neurophysiology phenotype of ninaC⁵

(Liu et al., 2008)

NOT Suppressor of

Statement

Reference

ninaE¹⁷/Rh3^Rh1+3 is a non-suppressor of abnormal neurophysiology phenotype of Arr2⁵

(Liu et al., 2008)

Other

Statement

Reference

Rh3^Rh1+3, ninaE¹⁷ has abnormal optomotor response phenotype

(Yamaguchi et al., 2008)

Phenotype Manifest In

Suppressed by

Statement

Reference

Rh3^Rh1+3 has ommatidium phenotype, suppressible by ninaC⁵

(Liu et al., 2008)

NOT suppressed by

Statement

Reference

Rh3^Rh1+3 has ommatidium phenotype, non-suppressible by ninaE¹⁷

(Liu et al., 2008)

Suppressor of

Statement

Reference

Rh3^Rh1+3 is a suppressor of ommatidium phenotype of ninaC⁵

(Liu et al., 2008)

Rh3^Rh1+3 is a suppressor of phenotype of ninaE¹⁷

(Feiler et al., 1992)

NOT Suppressor of

Statement

Reference

ninaE¹⁷/Rh3^Rh1+3 is a non-suppressor of ommatidium phenotype of Arr2⁵

(Liu et al., 2008)

Additional Comments

Genetic Interactions

Statement

Reference

In whole-cell voltage-clamp recording of dissociated ommatidia from Arr2⁵ flies carrying Rh3^Rh1+3 and mutant for ninaE¹⁷, the response to brief flashes of UV light inactivates normally but then fails to rapidly reach baseline leaving a secondary peak that decays over several seconds.

Flies expressing Rh3^Rh1+3 in the ninaC⁵ mutant background show that the slowly decaying tail is rapidly suppressed by photoreconversion of metarhodopsin to rhodopsin.

(Liu et al., 2008)

Rh3^Rh1+3, ninaE¹⁷ flies exhibit a shift in the point of equiluminance such that, compared with wild-type flies much less blue light is required to balace the standard green intensity, giving a blue/green ratio of 0.017 compared with 0.40 for wild-type flies.

(Yamaguchi et al., 2008)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

P^Rh1+3

(Yamaguchi et al., 2008)

Rh3^Rh1+3

Name Synonyms

Secondary FlyBase IDs

References (7)

Report Sections

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