FB2024_03 , released June 25, 2024
Allele: Dpse\perper.P
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General Information
Symbol
Dpse\perper.P
Species
D. pseudoobscura pseudoobscura
Name
FlyBase ID
FBal0029453
Feature type
allele
Associated gene
Dpse\per
Associated Insertion(s)
Carried in Construct
P{mps1}
Transgenic product class
wild_type
(Petersen et al., 1988)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Petersen et al., 1988)
Mutagen
in vitro construct
(Kyriacou, 1990, Petersen et al., 1988)
Progenitor genotype
Carried in construct
P{mps1}
Cytology
Description

4kb of 5' flanking DNA, the first (untranslated) exon and the first, large intron up to 350bp upstream of the second exon of D.melanogaster per is fused to approximately 190bp of the putative first intron, 50bp of the non-coding portion of exon 2, and the entire protein coding region, including six introns, of Dpse\per.

(Petersen et al., 1988)
Allele components
Component
Use(s)
Regulatory region(s)
per
Encoded product / tool
Dpse\per
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Introduction of P{Dpse\perper.P} construct (Petersen, EMBO J. 7: 3939) into per+ individuals successfully rescues circadian arrhythmicity, the circadian locomotor activity profiles resemble those of D.pseudoobscura.pseudoobscura (stronger rhythms with shorter periods).

      (Kyriacou, 1990)

      90% of per01 flies carrying one copy of Dpse\perper.P are arrhythmic, and the reamining 10% have a very weak rhythm. 30% of per01 flies carrying two copies of Dpse\perper.P show clear rescue of rhythmicity, with variable and long free running periods. The activity distribution and rest time values of these flies resemble those of D.pseudoobscura. per+ flies carrying Dpse\perper.P have free running periods the same length as in wild-type D.pseudoobscura.

      (Petersen et al., 1988)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Suppressor of
      Statement
      Reference

      Dpse\perper.P is a non-suppressor of abnormal locomotor rhythm phenotype of per01

      (Peixoto et al., 1998)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Fails to rescue the defective circadian locomotor activity periods of per01 mutants.

      (Peixoto et al., 1998)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Dpse\perper.P
      Name Synonyms
      Secondary FlyBase IDs
        References (5)