FlyBase Allele Report: Dmel\D[7]

General Information

Symbol

Dmel\D⁷

Species

D. melanogaster

Name

FlyBase ID

FBal0029152

Feature type

allele

Associated gene

Dmel\D

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

X ray

Nature of the Allele

Allele class

Mutagen

X ray

(Russell et al., 1996, Carpenter, 1994)

Progenitor genotype

Caused by aberration

T(2;3)D⁷

Cytology

Description

The aberration breakpoint is -16 to -18 kb 3' of the D transcription unit (where 0 indicates the translation start site).

(Sanchez Soriano and Russell, 2000)

Break in D maps to -16 to -18 where 0 is the translational start of D.

(Russell, 1999.1.25)

Breaks in 3' D regulatory sequences.

(Russell, 1998.3.2)

Breakpoint maps 3' to the D transcription unit.

(Russell et al., 1996)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Sanchez Soriano and Russell, 2000, Russell, 1999.1.25, Russell, 1998.3.2, Russell et al., 1996)

visible | dominant

(Sanchez Soriano and Russell, 2000, Russell, 1999.1.25, Russell, 1998.3.2, Carpenter, 1994)

Phenotype Manifest In

alula | posterior

(Russell, 2000)

wing

(Russell, 1999.1.25)

Detailed Description

Statement

Reference

Heterozygotes have defects in the posterior alar lobe.

(Russell, 2000)

Lethal when heterozygous with D^r72 or D^r513. The wing phenotype of the dominant alleles is due to ectopic expression of D in the anlage of the hinge in the wing imaginal disc, as can be reproduced using a D^Scer\UAS.cSa driven by Scer\GAL4^30A or Scer\GAL4^zfh2-MS209.

(Russell, 1999.1.25)

Lethal in combination with point alleles of D and small deletions which only remove D sequences.

(Russell, 1998.3.2)

Wings held out but also bent back at axil so appear to have a separation of 30-80^o, may also be held up or down. Alulae are reduced proximally, the remnant is a triangular flap with marginal bristles. Halteres are usually partially held down, may be either up or down. A and P supra-alar and A post-alar bristles are usually missing. Lethal over 70CD deficiencies.

(Carpenter, 1994)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions