FB2024_03 , released June 25, 2024
Allele: Dmel\parasbl-2
Open Close
General Information
Symbol
Dmel\parasbl-2
Species
D. melanogaster
Name
FlyBase ID
FBal0028467
Feature type
allele
Associated gene
Dmel\para
Associated Insertion(s)
P{}parasbl-2
Carried in Construct
Also Known As
olfDx9, parasbl2
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
ethyl methanesulfonate
(Ayyub et al., 1990)
Progenitor genotype
Associated Insertion(s)
P{}parasbl-2
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Arrhythmic visitors (per01) have no effect on the phase of locomotor rhythms in parasbl-2 hosts in studies of group-housed flies.

      (Levine et al., 2002)

      Homozygous and parasbl-1/parasbl-2 larvae do not disperse normally in a food source, showing reduced dispersal compared to wild-type larvae.

      (Kutzler et al., 1998)

      Heat sensitive period is from during embryonic development to prepupal stage, before the onset of metamorphosis. Cold sensitive period of females extends from after metamorphosis and includes the adult stage.

      (Lilly et al., 1994)

      Fails to complement paraID30 and parahd5 for viability. Homozygotes are viable and show a broadly based olfactory defect that alters their ability to respond to odorants representing multiple chemical classes. parasbl-2 flies show an aberrant larval olfactory response to propionic acid at dilutions spanning three orders of magnitude. Does not show temperature sensitive paralysis. Transheterozygotes with parahd1, parahd2 and parats1 show normal olfactory response to 10-1 propionic acid. Inviability is enhanced in a mlenap-ts1 background.

      (Lilly et al., 1994)

      Flies have a smell-blind phenotype with defective responses to benzaldehyde, ethyl acetate, iso-amyl acetate, acetic acid, propionic acid, ethanol and butanol.

      (Ayyub et al., 1990)

      Lower than wild type larval olfactory response to propionic acid, ethyl acetate and acetone. Also defective in contact chemosensory response. Females lay eggs at 29oC which then die as larvae: normal survival is seen at 25oC.

      (Lilly and Carlson, 1990)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      Rodrigues.

      Comments
      Comments

      Missense mutation that eliminates the 'olfactory specific' splice form of para through specific exon-skipping events.

      (Reenan et al., 1995)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (7)
      Reported As
      Symbol Synonym
      olfD
      (Dubin et al., 1998)
      olfDx9
      (Venkatesh, 2000, Carlson, 1991, Ayyub et al., 1990, Lilly and Carlson, 1990)
      parasbl-2
      parasbl2
      (Kutzler et al., 1998, Lilly et al., 1994)
      sbl2
      (Lilly et al., 1994)
      sblDx9
      sblolfD
      (Lilly and Carlson, 1990)
      Name Synonyms
      Secondary FlyBase IDs
        References (13)