FB2024_03 , released June 25, 2024
Allele: Dmel\parasbl-1
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General Information
Symbol
Dmel\parasbl-1
Species
D. melanogaster
Name
FlyBase ID
FBal0028466
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
parasbl1, sbl1
Key Links
Allele class
Nature of the Allele
Allele class
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

The social space index of mutant flies is not significantly different from wild-type controls.

Mutants do not show a change in sleep need after exposure to social enrichment, in contrast to control flies which show an increase in sleep requirement after exposure to social enrichment.

Arrhythmic visitors (per01) have no effect on the phase of locomotor rhythms in parasbl-1 hosts in studies of group-housed flies.

Homozygous and parasbl-1/parasbl-2 larvae do not disperse normally in a food source, showing reduced dispersal compared to wild-type larvae.

dncM11 and parasbl-1 males show increased courtship with Acp70Ag.Yp1.hs females than wild type males.

Homozygous flies do not show significant resistance to dichloro-diphenyl-trichloro ethane (DDT) compared to wild-type flies.

Heat sensitive period is from during embryonic development to prepupal stage, before the onset of metamorphosis. Cold sensitive period of females may begin as early as the embryonic stage and extends to the adult stage.

Fails to complement paraID30 and parahd5 for viability. Homozygotes are viable and show a broadly based olfactory defect that alters their ability to respond to odorants representing multiple chemical classes. Does not show temperature sensitive paralysis. Transheterozygotes with parahd1, parahd2 and parats1 show normal olfactory response to 10-1 propionic acid. Transheterozygotes of parats1 with parasbl-1, parasbl-5 and parasbl-6 show a significant increase in temperature sensitive paralysis compared to parats1/+ controls. Inviability is enhanced in a mlenap-ts1 background.

Defective in larval response to propionic acid and contact chemosensory response. Females lay eggs at 29oC which then die as larvae: normal survival is seen at 25oC.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer

Sziber.

Comments
Comments

Missense mutation that eliminates the 'olfactory specific' splice form of para through specific exon-skipping events.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (7)
References (18)