FlyBase Allele Report: Dmel\wg[l-15]

General Information

Symbol

Dmel\wg^l-15

Species

D. melanogaster

Name

FlyBase ID

FBal0018507

Feature type

allele

Associated gene

Dmel\wg

Associated Insertion(s)

Carried in Construct

Also Known As

wg^CX2

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - genetic evidence

Mutagen

X ray

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Couso and Martinez Arias, 1994)

Mutagen

X ray

(Baker, 1987)

Progenitor genotype

Cytology

Polytene chromosomes normal.

(Baker, 1987)

Description

Frameshift that leads to a deletion of the 23 C-terminal amino acids. Protein is not secreted.

(Couso and Martinez Arias, 1994)

Deletion of 374bp that removes the carboxy-terminal 23 amino acids.

(van den Heuvel et al., 1993)

0.3 kb deletion around position -8.

(Baker, 1987)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

delins

2L:7,315,117..7,315,490 [+]

Comment:

Deletion of 374bp that removes the carboxy-terminal 23 amino acids and extends into the 3' UTR. A G residue is inserted at the site of the deletion.

Inserted_sequence:

(van den Heuvel et al., 1993)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

wg^l-15 clones induced in the retina 42 hours after pupal formation contain fewer cone cells than controls. Loss of cone cells occurs if the clone is in the centre of the retina or at the edge.

wg^l-15 clones in the eye discs of third instar larvae have fewer cone cells than controls.

(Cordero and Cagan, 2010)

Clones in the antennal disc result in a severe reduction in the size of the disc. Adult flies carrying homozygous clones show a transformation of the dorsal head cuticle into ectopic eye tissue, and have missing antennae.

(Maurel-Zaffran and Treisman, 2000)

Embryos show lawn of denticles, with no naked cuticle.

(Couso and Martinez Arias, 1994)

No reduction in rate of germ band extension, in wg, ptc, en triple mutants.

(Irvine and Wieschaus, 1994)

embryonic lethal

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhancer of

Statement

Reference

wg^l-15 is an enhancer of wing phenotype of Scer\GAL4^vg.PM, sgg^S9A.UAS

(Collins and Treisman, 2000)

wg^l-15 is an enhancer of wing margin phenotype of Scer\GAL4^vg.PM, sgg^S9A.UAS

(Collins and Treisman, 2000)

Other

Statement

Reference

Mad^B1, wg^l-15 has photoreceptor neuron phenotype

(Hazelett et al., 1998)

Mad^B1, wg^l-15 has eye disc | posterior phenotype

(Hazelett et al., 1998)

Additional Comments

Genetic Interactions

Statement

Reference

Homozygous Mad^B1 wg^l-15 clones at the posterior margin of the eye disc autonomously fail to initiate photoreceptor development.

(Hazelett et al., 1998)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Kyoto

101418

CyO, Duox^Cy dpy^lv1 pr¹ cn² / wg^l-15 b¹ pr¹

Notes on Origin

Discoverer

Baker.

Comments

Similar characteristics to wg^l-17 and wg^S107. Shows weak allele-specific interaction with N^nd-2, and no interaction with N^M1.

(Couso and Martinez Arias, 1994)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

wg^CX2

(Cordero and Cagan, 2010, Collins and Treisman, 2000, Maurel-Zaffran and Treisman, 2000, Hazelett et al., 1998, Couso and Martinez Arias, 1994, Irvine and Wieschaus, 1994, van den Heuvel et al., 1993, Baker, 1987)

wg^l-15

Name Synonyms

Secondary FlyBase IDs

References (10)

Report Sections

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