FB2024_03 , released June 25, 2024
Allele: Dmel\vgU
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General Information
Symbol
Dmel\vgU
Species
D. melanogaster
Name
Ultra
FlyBase ID
FBal0017907
Feature type
allele
Associated gene
Dmel\vg
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

gain of function allele

Mutagen
Nature of the Allele
Allele class

gain of function allele

(Williams et al., 1990)
Mutagen
gamma ray
Progenitor genotype
Caused by aberration
In(2R)vgU
Cytology
Description

Inversion breakpoint within vg. This results in a fusion between mam and the distal part of the vg gene. The mam sequences fused to vg are intronic and the breakpoint in mam is at -27 (coordinates are as in FBrf0048222).

(Williams et al., 1990)

Fusion between mam and vg (second intron); proximal break ar +4 kb; '+' values to right (distal); 0 coordinate assigned to insert position of vg21; Williams, Atkin and Bell (1990)

Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Wing phenotype is unaffected by temperature.

      (Silber et al., 1997)

      Adults exhibit severely reduced wings. Margin structures are never observed and the entire wing blade appears to be deleted leaving only portions of the ventral wing hinge. Wing reduction can be suppressed by Egfrunspecified, suppression is variable.

      (Simmonds et al., 1997)

      Adults exhibit no wings.

      (Rabinow and Birchler, 1990)

      Heterozygotes have a severe reduction of wing and haltere. vgU/Df(2R)vg-B flies resemble the vg null phenotype, with complete wing and haltere reduction, female sterility, and erect postscutellar bristles.

      (Williams et al., 1990)

      One dose removes entire wing margin.

      (Williams and Bell, 1988)

      Heterozygotes have a vestigial wing phenotype. The wings lack margin structures. vgW/vgU flies are lethal and fail to emerge as adults. Lethal in combination with Df(2R)vg-C. Viable in combination with Df(2R)vg-B, Df(2R)vg-D and Df(2R)vg-S. vgU/Df(2R)vg-B and vgU/Df(2R)vg-D flies are sterile.

      (Bownes and Roberts, 1981)

      Hemizygous vgU/vg- survivors (50%) show extreme mutant phenotype. Partial revertant of vgU reported by Silber and Lemeunier (1981). homozygous lethal; dominant; vgU/+ has much reduced wings and halteres; vgU/vg1 has tiny wings, no halteres

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (4)
      Notes on Origin
      Discoverer

      Ives, 31st Dec. 1955.

      Comments
      Comments

      Analysis of a vgU revertant (vgUR2) indicates that sequences from the mam locus are required for vgU dominance. The homozygous embryonic lethality of In(2R)vgU may just be due to the mamU mutation. It is also possible that homozygous vgU dominance is lethal. No alteration in vgU dominance is seen in combination with zv77h, suggesting that the dominance is not produced by z- dependent transvection effects.

      (Williams et al., 1990)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      vgU
      (Ahmad and Henikoff, 2021, van de Bor et al., 1999)
      Name Synonyms
      Ultra
      Secondary FlyBase IDs
        References (11)