FlyBase Allele Report: Dmel\Ubx[bxd-100]

General Information

Symbol

Dmel\Ubx^bxd-100

Species

D. melanogaster

Name

FlyBase ID

FBal0017537

Feature type

allele

Associated gene

Dmel\Ubx

Associated Insertion(s)

Carried in Construct

Also Known As

bxd¹⁰⁰

Key Links

Allele class

Mutagen

X ray

Nature of the Allele

Allele class

Mutagen

X ray

(Bender et al., 1983)

Progenitor genotype

Caused by aberration

Tp(3;3)bxd¹⁰⁰

Cytology

Description

Breakpoint in Ubx.

(Castelli-Gair and Garcia-Bellido, 1990)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible | dominant

(Bender et al., 1985)

visible | homeotic (with Df(3R)P2)

(Rivlin et al., 2001)

wild-type

(Bender and Hudson, 2000)

Phenotype Manifest In

abdominal 1 ventral denticle belt

(Lindsley and Zimm, 1992)

abdominal 1 ventral denticle belt | embryonic stage

(Bender et al., 1985)

abdominal anterior fascicle & abdominal segment 1 & adult

(Teugels and Ghysen, 1985)

abdominal posterior fascicle & abdominal segment 1 & adult

(Teugels and Ghysen, 1985)

abdominal segment 1

(Lindsley and Zimm, 1992, Bender et al., 1985)

abdominal segment 2

(Lindsley and Zimm, 1992)

abdominal segment 3

(Lindsley and Zimm, 1992)

abdominal segment 4

(Lindsley and Zimm, 1992)

abdominal segment 5

(Lindsley and Zimm, 1992)

abdominal segment 6

(Lindsley and Zimm, 1992)

abdominal segment 7

(Lindsley and Zimm, 1992)

abdominal tergite 1

(Lindsley and Zimm, 1992, Bender et al., 1985)

adult abdominal segment 1 anterior compartment (with Df(3R)P2)

(Rivlin et al., 2001)

adult mesothoracic segment posterior compartment | ectopic (with Df(3R)P2)

(Rivlin et al., 2001)

adult metathoracic segment anterior compartment | ectopic (with Df(3R)P2)

(Rivlin et al., 2001)

adult metathoracic segment posterior compartment (with Df(3R)P2)

(Rivlin et al., 2001)

direct flight muscle cell | ectopic (with Df(3R)P2)

(Rivlin et al., 2001)

dorsal longitudinal indirect flight muscle cell | ectopic (with Df(3R)P2)

(Rivlin et al., 2001)

haltere

(Lindsley and Zimm, 1992, Bender et al., 1985)

haltere (with Ubx^{HC71-1.HC166D.Dup.Rec.ry+})

(Bender and Hudson, 2000)

histoblast nest | anterior | dorsal

(Frayne and Sato, 1991)

Keilin organ | embryonic stage

(Bender et al., 1985)

Kolbchen

(Lindsley and Zimm, 1992)

larval metathoracic segmental nerve | adult stage

(Teugels and Ghysen, 1985)

mesothoracic tergum (with Ubx^{HC71-1.HC166D.Dup.Rec.ry+})

(Bender and Hudson, 2000)

metathoracic segment

(Bender et al., 1985)

tergosternal muscle cell | ectopic (with Df(3R)P2)

(Rivlin et al., 2001)

tracheal pit

(Bender et al., 1985)

wing

(Lindsley and Zimm, 1992)

Detailed Description

Statement

Reference

Late homozygous embryos have normal oenocyte clusters.

(Brodu et al., 2002)

Ubx^bxd-100/Df(3R)P2 flies show transformation of the posterior compartment of T3 (T3p) and the anterior compartment of A1 (A1a) into T2p and T3a. The homeotically transformed T3 segment can contain DVM-I, DLM and DFM muscles. Homeotic DVM-II and DVM-III muscles are not seen.

(Rivlin et al., 2001)

When heterozygous with Ubx^{HC71-1.HC166D.Dup.Rec.ry+} the notum reduction phenotype is much more penetrant and severe. These animals also show an enlargement of the haltere, with anterior bristles, characteristic of a weak bx transformation.

(Bender and Hudson, 2000)

Transformation of posterior portion of haltere towards wing, loss of A1 tergite and appearance of T3 legs on A1. Ventral setal belt of A1 is transformed toward that of T3 and ventral pits appear on abdominal segments A1 to A7, inclusive.

(Lindsley and Zimm, 1992)

Ubx^bxd-100/Ubx^bxd-111 larvae have dorsal histoblast cells in T3. The anterior dorsal histoblast nests are sometimes inverted in flies transheterozygous or hemizygous for Ubx^bxd-100. The ventral histoblast nest of A1 is shifted to a more ventral position in Ubx^bxd-111/Ubx^bxd-100 flies.

(Frayne and Sato, 1991)

Hemizygotes display transformation of posterior haltere towards wing, loss of first abdominal tergite and appearance of one or two legs from the first abdominal segment. In late embryos and larvae ventral setal belt of the first abdominal segment is transformed toward that of the third thoracic segment. Ventral pits and Keilin organs appear on abdominal segments A1 to A7, inclusive.

(Bender et al., 1985)

Ubx^bxd-100/Ubx^bxd-125 flies have a number of abnormal transversal fascicles in the CNS; the posterior internal T3, posterior ventral T3, anterior dorsal A1, anterior internal A1, anterior ventral A1, posterior dorsal A1 and occasionally the posterior dorsal T3 fascicle are affected.

(Teugels and Ghysen, 1985)

The frequency of variegated bithorax transformations seen in Df(3R)red-P52 heterozygotes is not increased in flies also containing a copy of Ubx^bxd-100.

(Capdevila and Garcia-Bellido, 1981)

Heterozygotes with Ubx^bx-4 exhibit weak bx-like effects.

(Lewis, 1980)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Kyoto

103296

Df(3L)Pc Df(3R)bxd100, cp¹ in¹ kni^ri-1 Pc¹ p^p Ubx^bxd-100 / TM1, Me¹ kni^ri-1 Sb^sbd-l

Notes on Origin

Discoverer

E.B. Lewis

(Lindsley and Zimm, 1992)

Comments

The phenotype of a number of combinations of Ubx mutations has been investigated to determine the role of the bxd regulatory region in the modulation of Ubx expression.

(Castelli-Gair et al., 1992)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Ubx^bxd-100

Ubx^bxd100

(Brodu et al., 2002)

bxd100

(Camprodon and Castelli-Gair, 1994)

bxd¹⁰⁰

(Duncan, 2002, Rivlin et al., 2001, Lewis, 1998, Frayne and Sato, 1991, Irvine et al., 1991, Mathog, 1990, Botas et al., 1988, Lipshitz et al., 1987, Weinzierl et al., 1987, Bender et al., 1985, Teugels and Ghysen, 1985, Bender et al., 1983)

Name Synonyms

Secondary FlyBase IDs

References (21)

Report Sections

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