FB2024_03 , released June 25, 2024
Allele: Dmel\Ubxbxd-51j
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General Information
Symbol
Dmel\Ubxbxd-51j
Species
D. melanogaster
Name
FlyBase ID
FBal0017535
Feature type
allele
Associated gene
Dmel\Ubx
Associated Insertion(s)
gypsy{}Ubxbxd-51j
Carried in Construct
Also Known As
bxd51j
Key Links
Allele class

wild-type allele

Mutagen
Nature of the Allele
Allele class

wild-type allele

(Martinez-Laborda et al., 1996)
Mutagen
spontaneous
(Bender et al., 1983)
Progenitor genotype
Associated Insertion(s)
gypsy{}Ubxbxd-51j
Cytology

Polytene chromosomes normal.

(Castelli-Gair and Garcia-Bellido, 1990)
Description

Cis-regulatory mutation.

(LaJeunesse and Shearn, 1995)

Insertion of a gypsy element.

(Castelli-Gair et al., 1992)

Gypsy element insertion.

(Mathog, 1991)

gypsy element insertion into the bxd regulatory region. The direction of transcription of the gypsy element is in the opposite direction to Ubx transcription.

(Castelli-Gair and Garcia-Bellido, 1990)

Insertion of gypsy element.

(Mathog, 1990)

Insertion of a gypsy element. The direction of transcription of the gypsy element is opposite to the direction of transcription of Ubx.

(Micol et al., 1990)

gypsy insertion at map position -17.5kb.

(Bender et al., 1983)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      A few double heterozygotes for ash128 at 27oC exhibit haltere to wing transformation. Double heterozygotes for ash218 at 20oC or 27oC do not show homeotic transformations.

      (LaJeunesse and Shearn, 1995)

      Transformation of posterior portion of haltere towards wing, loss of A1 tergite and appearance of T3 legs on A1. Ventral setal belt of A1 is transformed toward that of T3 and ventral pits appear on abdominal segments A1 to A7, inclusive.

      (Lindsley and Zimm, 1992)

      Dominant transformation of first abdominal segment towards the third. Individuals carrying abd-A+ and Ubxbxd-51j have the complete abdominal leg phenotype, the phenotype is suppressed by two doses of abd-A.

      (Mathog, 1991)

      Does not affect the frequency of the trx bithorax-variegated phenotype in heterozygous combination with Df(3R)red-P52.

      (Castelli-Gair and Garcia-Bellido, 1990)

      Ubxbxd-51j/Df(3R)Ubx109 flies show complete loss of the first abdominal tergite, the haltere is enlarged, and there is a band of postnotal tissue in the dorsal third thoracic segment. Approximately 40% of these flies have extra legs.

      (Bender et al., 1983)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Other
      Statement
      Reference

      Ubxbx-3/Ubxbxd-51j, ssa has visible phenotype

      (Kuzin et al., 1997)
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      Ubxbxd-51j has phenotype, suppressible by su(Hw)unspecified

      (Bender et al., 1983)
      Other
      Statement
      Reference

      Ubxbx-3/Ubxbxd-51j, ssa has leg phenotype

      (Kuzin et al., 1997)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      ssa Ubxbx-3 Ubxbxd-51j hemizygotes do not emerge as imagos. Dissection of late pupae reveals flies have four pairs of legs (Ubxbx-3 Ubxbxd-51j phenotype) and the fourth pair of legs exhibit severe disruption of segmentation and an improvement in the segmentation of the third pair.

      (Kuzin et al., 1997)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments

      The mutant phenotype of bx homozygotes and heterozygotes for different bx alleles can be rescued by Ubxbxd-51j.

      (Martinez-Laborda et al., 1996)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      Lewis.

      (Lindsley and Zimm, 1992)
      Comments
      Comments

      The phenotype of a number of combinations of Ubx mutations has been investigated to determine the role of the bxd regulatory region in the modulation of Ubx expression.

      (Castelli-Gair et al., 1992)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      References (16)