FB2024_03 , released June 25, 2024
Allele: Dmel\Ubxbxd-1
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General Information
Symbol
Dmel\Ubxbxd-1
Species
D. melanogaster
Name
FlyBase ID
FBal0017532
Feature type
allele
Associated gene
Dmel\Ubx
Associated Insertion(s)
gypsy{}Ubxbxd-1
Carried in Construct
Also Known As
bxd1, bxd
Key Links
Allele class

wild-type allele

Mutagen
Nature of the Allele
Allele class

wild-type allele

(Martinez-Laborda et al., 1996)
Mutagen
spontaneous
(Bender et al., 1983)
Progenitor genotype
Associated Insertion(s)
gypsy{}Ubxbxd-1
Cytology

Polytene chromosomes normal.

(Castelli-Gair and Garcia-Bellido, 1990)
Description

Cis-regulatory mutation.

(LaJeunesse and Shearn, 1995)

gypsy element insertion into the bxd regulatory region. The direction of transcription of the gypsy element is in the same direction as Ubx transcription.

(Castelli-Gair and Garcia-Bellido, 1990)

Insertion of gypsy element.

(Mathog, 1990)

Insertion of a gypsy element. The direction of transcription of the gypsy element is the same as that of Ubx.

(Micol et al., 1990)

Insertion of a gypsy element.

(Harrison et al., 1989)

gypsy insertion at map position -21kb.

(Bender et al., 1983)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
M23335
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      A few double heterozygotes for ash128 at 27oC exhibit haltere to wing transformation and third to second leg transformation. Double heterozygotes for ash218 at 27oC exhibit very mild haltere to wing transformation.

      (LaJeunesse and Shearn, 1995)

      Ubx1/Ubxbxd-1 transheterozygotes show a A1a to T3a transformation.

      (Castelli-Gair et al., 1992)

      Transformation of posterior portion of haltere towards wing, loss of A1 tergite and appearance of T3 legs on A1. Ventral setal belt of A1 is transformed toward that of T3 and ventral pits appear on abdominal segments A1 to A7, inclusive.

      (Lindsley and Zimm, 1992)

      Does not affect the frequency of the trx bithorax-variegated phenotype in heterozygous combination with Df(3R)red-P52.

      (Castelli-Gair and Garcia-Bellido, 1990)

      Transheterozygotes with Ubx1 show an enhancement of the bx phenotype when in combination with E(bx)2. Haltere to winglike transformation is enhanced.

      (Bhosekar and Babu, 1987)

      Different genetic combinations of Pc alleles and Ubx alleles suggest that the products of the bx region of Ubx are responsible for the "cbx" phenotype of the Pc mutations and in the absence of Pc the overexpression of bx gene products suppresses the pbx insufficiency phenotype in the posterior segments.

      (Capdevila et al., 1986)

      Homozygous flies have normal transversal fascicles in the adult CNS. Ubxpbx-2/Df(3R)P10 flies have abnormal posterior internal T3 and anterior dorsal A1 fascicles and sometimes abnormal posterior dorsal T3, and anterior internal A1 fascicles.

      (Teugels and Ghysen, 1985)

      Ubxbxd-1/Df(3R)Ubx109 flies show complete loss of the first abdominal tergite, the haltere is slightly enlarged, and occasionally there is a thin band of postnotal tissue in the dorsal third thoracic segment. Approximately 20% of these flies have seven or eight legs.

      (Bender et al., 1983)

      The frequency of variegated bithorax transformations seen in Df(3R)red-P52 heterozygotes is not increased in flies also heterozygous for Ubxbxd-1.

      (Capdevila and Garcia-Bellido, 1981)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      Ubxbxd-1 has phenotype, enhanceable by Hel89B89B/Hel89B89B

      (Crosby et al., 1999)
      Suppressed by
      Statement
      Reference

      Ubxbxd-1 has phenotype, suppressible by su(Hw)unspecified

      (Bender et al., 1983)

      Ubxbxd-1 has phenotype, suppressible by su(Hw)2

      (Lindsley and Grell, 1968)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The phenotype of Ubxbxd-1 homozygotes is enhanced in double homozygous combination with Hel89B89B.

      (Crosby et al., 1999)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments

      The mutant phenotype of bx homozygotes and heterozygotes for different bx alleles can be rescued by Ubxbxd-1.

      (Martinez-Laborda et al., 1996)
      Images (0)
      Mutant
      Wild-type
      Stocks (4)
      Notes on Origin
      Discoverer

      Bridges.

      (Lindsley and Zimm, 1992)
      Comments
      Comments

      The phenotype of a number of combinations of Ubx mutations has been investigated to determine the role of the bxd regulatory region in the modulation of Ubx expression.

      (Castelli-Gair et al., 1992)
      External Crossreferences and Linkouts ( 1 )
      Crossreferences
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      Synonyms and Secondary IDs (3)
      References (27)