Nucleotide substitution: A?T.
A to T mutation at coordinate 3R:2485013 (release 5).
Amino acid replacement: term?L.
A6659291T
A2485013T
term186L | twr-PA
term186L
A mutation in the stop codon results in its replacement by Leu, causing an addition of 12 amino acids to be added to the C-terminal end of the protein.
The average number of crystal cells per embryo is reduced in homozygous stage 13-14 embryos (raised at the nonpermissive temperature of 30oC) compared to wild type.
Mutant eye (rough surface) and bristle (reduced and twisted) phenotype at 25oC and lethal at 28oC.
Wakimoto.
twr1 and twr11 contain the same mutation.