FB2024_03 , released June 25, 2024
Allele: Dmel\tub1
Open Close
General Information
Symbol
Dmel\tub1
Species
D. melanogaster
Name
FlyBase ID
FBal0017242
Feature type
allele
Associated gene
Dmel\tub
Associated Insertion(s)
Carried in Construct
Also Known As
tub118
Key Links
Genomic Maps

Allele class

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Ray et al., 1991)
Mutagen
ethyl methanesulfonate
(Hecht and Anderson, 1993)
Progenitor genotype
Cytology
Description

Point mutation substituting G for A, destroying the 3' splice site.

(Letsou et al., 1993)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:4,388,458..4,388,458 [+]
Nucleotide change:

G4388458A

Reported nucleotide change:

G?A

Comment:

Position of mutation on reference sequence inferred by FlyBase curator based on author statement. Mutation is in splice acceptor site.

(Letsou et al., 1993)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Level of Drs induction of bacterially challenged tub2/tub1 and tub3/tub1 mutants is lower than in wild type. Pattern of response of CecA1 and CecA2 parallels that of Drs. Dpt and Dro remain fully inducible and pattern of expression of AttA and Def in intermediate.

      (Lemaitre et al., 1996)

      Strongly dorsalised embryos. Transheterozygotes with tub2 are completely dorsalised, the phenotype of tub1 Tl3t/tub2 is unchanged from the transheterozygote.

      (Hecht and Anderson, 1993)

      Injected dl- perivitelline fluid had no effect on embryos.

      (Stein and Nusslein-Volhard, 1992)

      tub1/tub2 heterozygous embryos gastrulate symmetrically and secrete a twisted and hollow tube of dorsal cuticle.

      (Letsou et al., 1991)

      Dorsalized embryos: all cuticle cells along the dorsoventral axis behave like dorsal cells of the wild type embryo. zen expression pattern refines at stage 5, dpp pattern does not refine at all, twi and sna are expressed during late stages of embryogenesis.

      (Ray et al., 1991)

      Embryos derived from homozygous females are dorsalised.

      (Carroll et al., 1987)

      Embryos can be rescued with wild-type cytoplasm and RNA; however, none hatch.

      (Anderson and Nusslein-Volhard, 1984)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Double mutant combinations with eaD1 are strongly dorsalizing.

      (Chasan et al., 1992)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Molecular modification is predicted to eliminate splicing.

      (Letsou et al., 1993)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      References (21)