FB2024_03 , released June 25, 2024
Allele: Dmel\trk2
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General Information
Symbol
Dmel\trk2
Species
D. melanogaster
Name
FlyBase ID
FBal0017040
Feature type
allele
Associated gene
Dmel\trk
Associated Insertion(s)
Carried in Construct
Also Known As
trkHD
Key Links
Genomic Maps

Allele class

loss of function allele

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Casanova et al., 1995)

loss of function allele

(Pignoni et al., 1992)
Mutagen
ethyl methanesulfonate
(Casanova et al., 1995, Schupbach and Wieschaus, 1989)
Progenitor genotype
Cytology
Description

Amino acid replacement: C168S.

(Casanova, 1999.9.6)

Nucleotide substitution: TGC changed to AGC.

(Casanova, 1999.9.6)

Point mutation within the Cys arrangement in the putative coding sequence. Amino acid replacement: C168S.

(Casanova et al., 1995)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2L:10,271,678..10,271,678 [-]
Nucleotide change:

T10271678A

Reported nucleotide change:

T?A

Amino acid change:

C178S | trk-PA

Reported amino acid change:

C169S

Comment:

Difference between reported and annotated amino acid number is due to authors using M10 as the start Met.

(Casanova et al., 1995)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      trk2 deletes the terminal regions in tll embryos. Little or no tll expression is detected in the posterior of syncytial or cellular blastoderm embryos, at the anterior the early tll cap does not appear and an abnormal anterior tll stripe appears by the late syncytial blastoderm.

      (Pignoni et al., 1992)

      Eggs derived from homozygous females cellularise normally but become abnormal at gastrulation; the cephalic furrow is shifted forward, the posterior midgut is missing and the germband forms to the posterior end of the embryo. The embryos lack anterior head structures and structures posterior to segment A7 (the labral segment and telson).

      (Schupbach and Wieschaus, 1989)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      Comments
      Comments

      A strong allele of trk.

      (Pignoni et al., 1992)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      trk2
      (Casanova, 1999.9.6)
      trkHD8
      (Sprenger and Nusslein-Volhard, 1993, Sprenger et al., 1993)
      trkHD
      (Pignoni et al., 1992, Grau and Gutzeit, 1990)
      Name Synonyms
      Secondary FlyBase IDs
        References (7)