Amino acid replacement: D728Y. Nucleotide substitution: G2182T.
G24752372T
G2182T
D738Y | tld-PA
D728Y
Position of mutation on reference sequence inferred by FlyBase curator. Difference beteween actual and reported amino acid substitution due to authors using M11 as the start Met.
Shows third larval instar lethality when heterozygous with the MBT chromosome. Brain tumours are seen.
Weak ventralised phenotype. Defective movements of the germ band: due to loss of the amnioserosa and because the dorsalmost cells have acquired the lateral fate of the dorsal ectoderm. Dorsal cell fates are deleted and ventrolateral mitotic domains are expanded.
Temperature sensitive period is one hour immediately preceding gastrulation.
Weak, completely penetrant tld allele.