FB2024_03 , released June 25, 2024
Allele: Dmel\Tl1
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General Information
Symbol
Dmel\Tl1
Species
D. melanogaster
Name
FlyBase ID
FBal0016826
Feature type
allele
Associated gene
Dmel\Tl
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

gain of function allele

Mutagen
Nature of the Allele
Allele class

gain of function allele

(Schneider et al., 1991)
Mutagen
ethyl methanesulfonate
(Tearle and Nusslein-Volhard, 1987, Anderson et al., 1985)
Progenitor genotype
Cytology

Polytene chromosomes normal.

(Anderson et al., 1985)
Description

Nucleotide substitution: G2838A. Amino acid replacement: C755Y. This mutation is in the extracellular domain of the protein.

(Schneider et al., 1991)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:26,840,117..26,840,117 [+]
Nucleotide change:

G26840117A

Reported nucleotide change:

G2838A

Amino acid change:

C755Y | Tl-PB; C755Y | Tl-PC; C755Y | Tl-PD

Reported amino acid change:

C755Y

Comment:

This mutation is in the extracellular domain of the protein.

(Schneider et al., 1991)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Ventralised embryos.

      (Hecht and Anderson, 1993)

      Embryos from heterozygous females are strongly ventralised; the ventral epidermis is expanded, there is complete loss of dorsal epidermis and the mesoderm is not expanded. Females carrying Tl1 in trans with a null allele of Tl produce ventralised embryos.

      (Schneider et al., 1991)

      Females carrying Tl1 produce embryos in which the ventral and lateral structures are enlarged at the expense of dorsal structures.

      (Schupbach and Wieschaus, 1986)

      dominant

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Germline mosaic analysis shows that Tl is required in the germline.

      (Schupbach and Wieschaus, 1986)

      Class I allele.

      (Schneider et al., 1991)

      Class I Tl allele.

      (Hecht and Anderson, 1993)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Tl1
      Name Synonyms
      Secondary FlyBase IDs
        References (7)