FB2024_03 , released June 25, 2024
Allele: Dmel\t1
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General Information
Symbol
Dmel\t1
Species
D. melanogaster
Name
FlyBase ID
FBal0016714
Feature type
allele
Associated gene
Dmel\t
Associated Insertion(s)
Carried in Construct
Also Known As
tan1
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
spontaneous
(Lindsley and Zimm, 1992)
Progenitor genotype
Cytology
Description

Amino acid replacement: R217P.

(True et al., 2005)

Tyrosinase active in adult.

(Lindsley and Grell, 1968)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:9,218,876..9,218,876 [-]
Nucleotide change:

G9218876C

Amino acid change:

R217P | t-PA; R217P | t-PB

Reported amino acid change:

R217P

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change

(True et al., 2005)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The overall architecture of the retina and lamina of the eye is not altered in homozygotes.

      (Stenesen et al., 2015)

      t1/t1 mutants or mosaic flies with homozygous t1/t1 photoreceptors (but elsewhere heterozygous) do not show on or off transients in response to light in electroretinogram recordings (ERGs) and have significantly reduced phototaxis compared to wild type.

      (Xu et al., 2015)

      t1 mutants are defective in the hydrolysis of carcinine.

      Photoreceptor terminals in t1 mutants exhibit a reduced number of synaptic vesicles. The density of these synaptic vesicles is approximately 30% of wild-type.

      t1 flies do not exhibit ON and OFF transients in ERG recordings of the laminar LMC neurons at the onset and end of light stimulation.

      Approximately 65% of HdcJK910 mutants show no visual alert response (to a moving block, than in wild-type freezes fly movement). Approximately 25% exhibit a delayed response.

      (Chaturvedi et al., 2014)

      Body color: tan.

      (True et al., 2005)

      There are fewer synaptic vesicles per R1-R6 photoreceptor terminal in t1 mutants than in wild type.

      (Borycz et al., 2002)

      Homozygous third instar larvae show a normal response to UVC radiation.

      (Baden et al., 1996)

      N-Β-alanyldopamine levels are elevated approximately threefold in homozygous flies compared to wild-type, while dopamine levels are reduced to about 50% of wild-type levels. High levels of N-Β-alanyldopamine are excreted compared to wild-type. When unpigmented t1 pharate adult tissue is incubated with dopamine in vitro, the extent of inducible pigmentation of body cuticle, hairs and bristle sockets resembles that of wild-type, while pigmentation of the bristle shafts is significantly reduced.

      (Walter et al., 1996)

      Body colour: more tan than wild type; easiest to identify by light tan antennae; male easier than female.

      (Lindsley and Zimm, 1992)

      Dopamine, an important component of catecholamine metabolism (involved in both melanization of cuticle and synthesis of neurotransmitters), has been found in reduced amounts (about 60% of the wild-type concentration) in t1 and t5.

      (Konopka, 1972)

      ERG abnormal.

      (Benzer, 1967)

      Larval mouth part colour: lighter than normal at basal prongs, classifiable with difficulty in larva.

      (Brehme, 1941)

      Not positively phototactic.

      (McEwen, 1918)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      NOT suppressed by
      Statement
      Reference

      t1 has phenotype, non-suppressible by su(Hw)2

      (Lindsley and Grell, 1968)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      td07784

      (True et al., 2005)

      t10

      (Lindsley and Zimm, 1992)

      t9

      (Lindsley and Zimm, 1992)

      t6

      (Lindsley and Zimm, 1992)

      t5

      (Benzer, 1967)
      Rescued by

      t1 is rescued by Scer\GAL4C-765/tUAS.cTa

      (True et al., 2005)

      t1 is rescued by Scer\GAL4ptc-559.1/tUAS.cTa

      (True et al., 2005)
      Comments

      No complementation for body color or phototaxis between t1 and t6. No complementation for body color or phototaxis between t1 and t10. No complementation for body color or phototaxis between t1 and t9.

      (Lindsley and Zimm, 1992)
      Images (0)
      Mutant
      Wild-type
      Stocks (14)
      Notes on Origin
      Discoverer

      Bridges, 16th July 1914.

      (Lindsley and Zimm, 1992)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      t1
      (Titus et al., 2023, Borycz et al., 2008)
      tan1
      (Xu et al., 2015, True et al., 2005, Borycz et al., 2002)
      Name Synonyms
      tan1
      (Stenesen et al., 2015, Chaturvedi et al., 2014)
      Secondary FlyBase IDs
        References (18)