FB2024_03 , released June 25, 2024
Allele: Dmel\SxlM3
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General Information
Symbol
Dmel\SxlM3
Species
D. melanogaster
Name
FlyBase ID
FBal0016709
Feature type
allele
Associated gene
Dmel\Sxl
Associated Insertion(s)
H{}SxlM3
Carried in Construct
Key Links
Genomic Maps

Allele class

gain of function allele

Mutagen
Nature of the Allele
Allele class

gain of function allele

(Maine et al., 1985)
Mutagen
spontaneous
(Bernstein et al., 1995, Lindsley and Zimm, 1992, Maine et al., 1985)
Progenitor genotype
Associated Insertion(s)
H{}SxlM3
Cytology
Description

A 3.5kb hobo is inserted into the 3' splice site of the male-specific exon 3. The hobo is transcribed in the same direction as Sxl.

(Bernstein et al., 1995)

~5 kb hobo insertion near male-specific exon 3. Shown to be a hobo (Bernstein, 1989) rather than 297 as originally reported.

(Lindsley and Zimm, 1992)

Insert stated as cause: 297{} Insertion of approximately 5kb 297 element into Sxl, approximately 1kb proximal to the site of roo element insertion in SxlM1. SxlM3 and SxlM5 are similar at the molecular level.

(Maine et al., 1985)
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The SxlM alleles differ in their ability to bypass the X:A signal. SxlM4 is more effective than SxlM3, is more effective than SxlM1, at suppressing female-specific zygotic lethality of sisA and scsisB mutations.

      (Bernstein et al., 1995)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Insertion is a hobo as opposed to the previously reported 297 element. The SxlM3 chromosome has become fixed for In(1)M3.

      (Bernstein et al., 1995)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      SxlM#3
      (Maine et al., 1985)
      SxlM3
      Name Synonyms
      Secondary FlyBase IDs
        References (3)