FlyBase Allele Report: Dmel\sna[6]

General Information

Symbol

Dmel\sna⁶

Species

D. melanogaster

Name

FlyBase ID

FBal0015892

Feature type

allele

Associated gene

Dmel\sna

Associated Insertion(s)

Carried in Construct

Also Known As

sna^RY1

Key Links

Allele class

amorphic allele - genetic evidence

Mutagen

X ray

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Reuter et al., 1993)

Mutagen

X ray

(Ashburner et al., 1999.10.12, Roote, 1995.5.4, Grau et al., 1984, Simpson, 1983)

Progenitor genotype

Cytology

Polytene chromosomes normal.

(Grau et al., 1984, Simpson, 1983)

Description

Carries a 1.6kb deletion at the sna locus.

(Boulay et al., 1987)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Grau et al., 1984)

lethal - all die during embryonic stage | recessive

(Reuter et al., 1993, Ashburner et al., 1990)

some die during embryonic stage | recessive

(Reuter et al., 1993, Ashburner et al., 1990)

Phenotype Manifest In

adult thorax

(Grau et al., 1984)

anterior midgut primordium

(Reuter et al., 1993)

haltere

(Grau et al., 1984)

posterior midgut primordium

(Reuter et al., 1993)

ventral denticle belt

(Grau et al., 1984)

ventral furrow

(Grau et al., 1984)

visceral mesoderm

(Reuter et al., 1993)

Detailed Description

Statement

Reference

In spite of normal AMG and PMG invagination, neither anterior nor posterior midgut primordia shows any sign of extension towards each other, but remain as large mesenchymal cell masses immersed in yolk at the ends of the embryo. The cells of these primordia fail to arrange into an epithelium.

(Reuter et al., 1993)

Ventral furrow fails to form.

(Ashburner et al., 1990)

Strong allele.

(Boulay et al., 1987)

Embryos are partially dorsalised.

(Carroll et al., 1987)

sna⁶/Tp(2;1)Sco^rv23 adult escapers are occasionally produced, which often have missing halteres or show a hemithorax phenotype. Homozygous embryos fail to form a ventral furrow. Cephalic furrow formation, invagination of the endoderm and germ band elongation do take place in these embryos. Embryos show varying defects in the segmental denticle belts.

(Grau et al., 1984)

strong allele;

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

sna^Sco-rv15

(Grau et al., 1984)

sna¹⁸

(Grau et al., 1984)

sna⁵

(Grau et al., 1984)

sna⁴

(Grau et al., 1984)

sna³

(Grau et al., 1984)

sna²

(Grau et al., 1984)

sna¹

(Grau et al., 1984)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Simpson.

P. Simpson.

(Roote, 1995.5.4, Simpson, 1983)

Comments

Phenotypic data included in FBrf0051973.

(Roote, 1995.5.4)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

RY1

(Roote, 1995.5.4, Boulay et al., 1987)

sna⁶

sna^RY1

(Reuter and Leptin, 1994, Reuter et al., 1993, Alberga et al., 1991, Ashburner et al., 1990, Grau et al., 1984)

sna^ry1

(Carroll et al., 1987, Simpson, 1983)

Name Synonyms

Secondary FlyBase IDs

References (10)

Report Sections

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