FB2024_03 , released June 25, 2024
Allele: Dmel\sim6
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General Information
Symbol
Dmel\sim6
Species
D. melanogaster
Name
FlyBase ID
FBal0015661
Feature type
allele
Associated gene
Dmel\sim
Associated Insertion(s)
Carried in Construct
Also Known As
simB21-2, l(3)B21-2
Key Links
Allele class

hypomorphic allele - genetic evidence

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Thomas et al., 1988)

hypomorphic allele - genetic evidence

(Xiao et al., 1996, Nambu et al., 1990)
Mutagen
ethyl methanesulfonate
(Nambu et al., 1990, Hilliker et al., 1981)
Progenitor genotype
Cytology
Description

Nucleotide substitution: C?T.

(Freer et al., 2011)

Amino acid replacement: Q561term.

(Freer et al., 2011)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Commissures fail to form and the longitudinal tracts collapse into a fused tract at the midline.

      (Therianos et al., 1995)

      The presence of Ecol\lacZsim.7.8 construct fails to rescue lethality or the CNS phenotype. The construct shows that the midline cells are disorganised compared to wild type at stage 11 and at stage 13 are clustered near the ventral surface of the embryo leading to the collapse of the two lateral CNS hemiganglia and fusion of the longitudinal connectives.

      (Nambu et al., 1990)

      CNS defect: specific alterations in the pattern of precursors that give rise to the 2 MP1 progeny, ventral unpaired median neurons and the specialized ectodermal cells, the midline ectodermal cells (MEC).

      (Thomas et al., 1988)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      l(3)B21-2
      (Thomas et al., 1988, Hilliker et al., 1981)
      sim6
      (Freer et al., 2011, Freer et al., 2011)
      simB21-2
      (Xiao et al., 1996, Mellerick and Nirenberg, 1995, Nambu et al., 1990)
      simB21.2
      (Therianos et al., 1995)
      Name Synonyms
      Secondary FlyBase IDs
        References (8)