FB2024_03 , released June 25, 2024
Allele: Dmel\Sh6
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General Information
Symbol
Dmel\Sh6
Species
D. melanogaster
Name
FlyBase ID
FBal0015546
Feature type
allele
Associated gene
Dmel\Sh
Associated Insertion(s)
Carried in Construct
Also Known As
Sh101
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Barros et al., 1991)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Sh6 flies treated with sodium valproate (NaVP) show a reduction in body weight, as is seen in wild-type flies. Treatment of Sh6 flies with NaVP causes an increase in mortality as is seen in wild-type flies.

      (Sharma and Kumar, 1999)

      Flies are significantly more sensitive to acrolein than wild-type flies.

      (Barros et al., 1991)

      Normal electroretinogram.

      (Homyk and Pye, 1989)

      abnormal leg shaking under ether anesthesia

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Other
      Statement
      Reference

      Flutterunspecified, Sh6 has abnormal flight | dominant | heat sensitive phenotype

      (Homyk, 1991)

      Flutterunspecified, Sh6 has abnormal locomotor behavior | dominant | heat sensitive phenotype

      (Homyk, 1991)
      Phenotype Manifest In
      Other
      Statement
      Reference

      Flutterunspecified, Sh6 has mesothoracic leg phenotype

      (Homyk, 1991)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Fluunspecified Sh6 double heterozygotes hop and fly poorly compared to either single heterozygote at 29oC. Fluunspecified Sh6 double heterozygotes walk and climb normally when raised at 22oC up to seven days after eclosion. After this time there is a gradual loss of function of the mesothoracic legs, first noticeable in their lack of use for climbing. Paralysis of the legs is usually accompanied by formation of a black spot, resembling a wound reaction, at the region of the trochanter and the femoral coxal joint.

      (Homyk, 1991)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer

      Homyk.

      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Sh101
      (Barros et al., 1991, Homyk, 1991, Homyk and Pye, 1989)
      Sh6
      Name Synonyms
      Secondary FlyBase IDs
        References (5)