FlyBase Allele Report: Dmel\sev[3]

General Information

Symbol

Dmel\sev³

Species

D. melanogaster

Name

FlyBase ID

FBal0015447

Feature type

allele

Associated gene

Dmel\sev

Associated Insertion(s)

Carried in Construct

Also Known As

sev^E1

Key Links

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy

(Petrovic and Hummel, 2008)

Phenotype Manifest In

photoreceptor cell R7

(Petrovic and Hummel, 2008, Karpilow et al., 1996, Rogge et al., 1991)

Detailed Description

Statement

Reference

sev³ mutant flies lack R7 photoreceptor cells.

(Petrovic and Hummel, 2008)

Eliminates R7 cell. In sev³ ort¹ double mutants only R8 cells exhibit intact rhabdomeres.

(Karpilow et al., 1996)

positive phototaxis with Ppb/+

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

Scer\GAL4^GMR.long, seq^UAS.cBa, sev³ has abnormal neuroanatomy phenotype

(Petrovic and Hummel, 2008)

Phenotype Manifest In

Other

Statement

Reference

Scer\GAL4^GMR.long, seq^UAS.cBa, sev³ has photoreceptor cell R7 phenotype

(Petrovic and Hummel, 2008)

Scer\GAL4^GMR.long, seq^UAS.cBa, sev³ has medulla layer M3 phenotype

(Petrovic and Hummel, 2008)

Scer\GAL4^GMR.long, seq^UAS.cBa, sev³ has medulla layer M6 phenotype

(Petrovic and Hummel, 2008)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of seq^Scer\UAS.cBa under the control of Scer\GAL4^GMR.long induces the R7 photoreceptor cells in sev³ mutants to switch from targeting the M3 layer of the medulla to the M6 layer.

(Petrovic and Hummel, 2008)

Sos^JC2 does not suppress the mutant phenotype, R7 cells are absent from ommatidia.

(Rogge et al., 1991)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

sev³

sev^E1

(Petrovic and Hummel, 2008, Rogge et al., 1991)

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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