FB2024_03 , released June 25, 2024
Allele: Dmel\Scr13A
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General Information
Symbol
Dmel\Scr13A
Species
D. melanogaster
Name
FlyBase ID
FBal0015315
Feature type
allele
Associated gene
Dmel\Scr
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Sivanantharajah and Percival-Smith, 2009)
Mutagen
ethyl methanesulfonate
(Tearle and Nusslein-Volhard, 1987)
Progenitor genotype
Cytology
Description

Nucleotide substitution: G781T.

(Sivanantharajah and Percival-Smith, 2009)

Amino acid replacement: G261term.

(Sivanantharajah and Percival-Smith, 2009)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:6,841,400..6,841,400 [-]
Nucleotide change:

G6841400T

Reported nucleotide change:

G781T

Amino acid change:

G261term | Scr-PA; G261term | Scr-PB; G261term | Scr-PD; G261term | Scr-PE; G261term | Scr-PF

Reported amino acid change:

G261term

(Sivanantharajah and Percival-Smith, 2009)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In

      embryonic/larval salivary gland (with Scr3)

      (Sivanantharajah and Percival-Smith, 2009)

      embryonic/larval salivary gland (with Scr15)

      (Sivanantharajah and Percival-Smith, 2009)

      labellum | cell autonomous | somatic clone

      (Struhl, 1982)

      maxillary palp | cell autonomous | ectopic | somatic clone

      (Struhl, 1982)

      maxillary palp | ectopic | somatic clone

      (Sivanantharajah and Percival-Smith, 2009)

      mesothoracic leg | cell autonomous | ectopic | somatic clone

      (Struhl, 1982)

      proboscis | cell autonomous | somatic clone

      (Struhl, 1982)

      proboscis | somatic clone

      (Sivanantharajah and Percival-Smith, 2009)

      prothoracic leg | cell autonomous | somatic clone

      (Struhl, 1982)

      pseudotrachea (with Scr3)

      (Sivanantharajah and Percival-Smith, 2009)

      pseudotrachea (with Scr5)

      (Sivanantharajah and Percival-Smith, 2009)

      pseudotrachea (with Scr7)

      (Sivanantharajah and Percival-Smith, 2009)

      pseudotrachea (with Scr8)

      (Sivanantharajah and Percival-Smith, 2009)

      pseudotrachea (with Scr14)

      (Sivanantharajah and Percival-Smith, 2009)

      pseudotrachea | somatic clone

      (Sivanantharajah and Percival-Smith, 2009)

      sex comb

      (Moazzen et al., 2009, Sivanantharajah and Percival-Smith, 2009)

      sex comb (with Scr3)

      (Sivanantharajah and Percival-Smith, 2009)

      sex comb (with Scr5)

      (Sivanantharajah and Percival-Smith, 2009)

      sex comb (with Scr6)

      (Sivanantharajah and Percival-Smith, 2009)

      sex comb (with Scr7)

      (Sivanantharajah and Percival-Smith, 2009)

      sex comb (with Scr8)

      (Sivanantharajah and Percival-Smith, 2009)

      sex comb (with Scr14)

      (Sivanantharajah and Percival-Smith, 2009)

      sex comb (with Scr15)

      (Sivanantharajah and Percival-Smith, 2009)
      Detailed Description
      Statement
      Reference

      Males heterozygous for Scr13Ashow a significant loss of sex comb bristles.

      (Moazzen et al., 2009)

      Homozygous clones in the proboscis are completely transformed towards maxillary palp identity and pseudotrachea do not form.

      Scr3/Scr13A, Scr5/Scr13A, Scr7/Scr13A, Scr8/Scr13A and Scr14/Scr13A flies have a reduced number of rows of pseudotrachea on the proboscis compared to controls.

      Heterozygous males have a reduction in the number of sex comb bristles on the prothoracic leg compared to wild-type males.

      (Sivanantharajah and Percival-Smith, 2009)

      Homozygous clones induced at the blastoderm stage or larval stage cause autonomous transformation of the first leg into the second leg. Clones in the proboscis autonomous transformed the labial palps into maxillary palps. Scr13A Ubx1 clones induced at the blastoderm stage is the additive phenotype of Scr13A and Ubx1 clones, prothorax is transformed to metathorax.

      (Struhl, 1982)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Scr13A
      (Jordan et al., 2002)
      Scr13A
      (Moazzen et al., 2009, Sivanantharajah and Percival-Smith, 2009, Percival-Smith et al., 2005)
      Name Synonyms
      Secondary FlyBase IDs
        References (8)