FB2024_04 , released June 25, 2024
Allele: Dmel\ry506
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General Information
Symbol
Dmel\ry506
Species
D. melanogaster
Name
FlyBase ID
FBal0015008
Feature type
allele
Associated gene
Dmel\ry
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - genetic evidence

loss of function allele

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Dunkov et al., 1991, Lucchesi and Manning, 1988)

loss of function allele

(Lindsley and Zimm, 1992)
Mutagen
gamma ray
(Lindsley and Zimm, 1992)
Progenitor genotype
ry+5
(Sekelsky, 1999.10.10, Hilliker et al., 1992, Reaume et al., 1991, Reaume et al., 1989, Daniels et al., 1985)
Cytology
Description

The ry506 deletion begins at +1397 (GTGCATTG...) and proceeds through +4885 (...TTATGAAAC). There is an insertion of a single A between the breakpoints (unless this A is a polymorphism on the ry+5 chromosome at +4885).

(Sekelsky, 1999.10.10)

Deletion of two thirds of the 3' end of the gene.

(Hughes et al., 1992)

3.4 kb deletion between +1.1 and +5.0 kb.

(Lindsley and Zimm, 1992)

Deletion mutant.

(Dunkov et al., 1991)

The 3' half of the coding region is deleted.

(Reaume et al., 1991)

Deletion of approximately one-third of the coding region.

(Reaume et al., 1989)

Deletion of ry coding sequences.

(Lucchesi and Manning, 1988)

Deletion of ry sequences, including at least some of the protein coding region.

(Daniels et al., 1985)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
delins
3R:13,035,565..13,039,049 [+]
Inserted_sequence:

A

Comment:

A deletion of approximately one-third of the coding region beginning at the sequence GTGCATTG and ending at TTATGAAAC. There is an insertion of a single A between the breakpoints.

(Sekelsky, 1999.10.10, Reaume et al., 1989)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  xanthinuria
      CEA
      (Wang and Spradling, 2022)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      21-days old ry506 mutant adults raised at 29[o]C do not show significantly changes in PPL1 neurons, as compared to age-matched controls.

      (Cunningham et al., 2018)

      ry506 homozygotes show increased mortality but no effect on developmental time when exposed to ethanol during development compared to controls.

      (Logan-Garbisch et al., 2014)

      The response of ry506 mutants to paraquat is similar to wild-type flies.

      (Wang et al., 2003)

      Homozygotes are hypersensitive to paraquat, hyperoxia and γ-radiation. ry506 Sodn1 double homozygotes die during late metamorphosis and during the process of eclosion.

      (Hilliker et al., 1992)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Statement
      Reference

      ry506 has abnormal eye color phenotype, suppressible by Ccap\Xdhhs.PP

      (Pitts and Zwiebel, 2001)
      NOT Enhancer of
      Statement
      Reference

      ry506/ry506 is a non-enhancer of chemical resistant | dominant phenotype of pucE69

      (Wang et al., 2003)
      Other
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      ry506 has pigment cell phenotype, suppressible by Ccap\Xdhhs.PP

      (Pitts and Zwiebel, 2001)
      Other
      Statement
      Reference

      ry506, whd1 has wing phenotype

      (Strub et al., 2008)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      whd1 ry506 double homozygotes have a much more severe wing phenotype than either single homozygote.

      (Strub et al., 2008)

      The response of pucE69/+ flies to paraquat is not affected when flies have a ry506 genetic background.

      (Wang et al., 2003)

      The double mutant combination Zwn1/Y ry506/ry506 or Zwn3/Y ry506/ry506 is usually lethal. Escaper Zwn1/Y ry506/ry506 flies live for only a few days and appear to be sterile.

      (Lucchesi and Manning, 1988)
      Xenogenetic Interactions
      Statement
      Reference

      Expression of Ccap\Xdhhs.PP using heat shock in ry506 animals results in flies with wild-type eye pigmentation.

      (Pitts and Zwiebel, 2001)
      Complementation and Rescue Data
      Rescued by

      ry506 is rescued by ry+t7.2

      (McMahan et al., 2013)
      Partially rescued by

      ry506 is partially rescued by ry606N

      (McMahan et al., 2013)

      ry506 is partially rescued by ry609N

      (McMahan et al., 2013)
      Comments

      One copy of ry+t7.2 restores full viability of homozygous ry506 flies on purine selection.

      ry606N and ry609N each rescue wild-type eye colour but not survival on purine selection in ry506 flies.

      (McMahan et al., 2013)
      Images (2)
      Stocks (1,626)
      Notes on Origin
      Discoverer

      Gelbart.

      (Lindsley and Zimm, 1992)
      Comments
      Comments

      Dia2 enzyme activity is missing in ry506 mutants.

      (Dunkov et al., 1991)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      References (37)