FB2024_03 , released June 25, 2024
Allele: Dmel\rut2
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General Information
Symbol
Dmel\rut2
Species
D. melanogaster
Name
FlyBase ID
FBal0014879
Feature type
allele
Associated gene
Dmel\rut
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Feany, 1990)
Mutagen
ethyl methanesulfonate
(Feany, 1990)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mutant males lack 30-minute courtship memory after 1 hour of conditioning in a courtship conditioning assay. This defect is significantly suppressed if the males are fed 0.1mM 20-hydroxy-ecdysone for 10 minutes immediately prior to conditioning.

      (Ishimoto et al., 2013)

      The peak dihydropyridine (DHP)-sensitive current in rut2 larval muscles is significantly decreased (78.6 +/- 7.5% of wild-type value) compared to wild type. The current can be increased to 88.2 +/- 3.7% of wild type by application of 1μm forskolin. The peak current is not inhibited by 10 μm H-89 (a PKA inhibitor).

      (Bhattacharya et al., 1999)

      Mutant diminishes cAMP synthesis and reduced the rate of habituation (using the jump-and-flight escape response). Habituation is extremely rapid in dnc rut double mutants.

      (Engel and Wu, 1996)

      Reduction in basal level of adult adenylate cyclase. Calcium sensitive. Transheterozygote females dncM14/rut2 and dncM14/rut3 deposit eggs that lack germ cells and display discrete morphological defects.

      (Whitehouse-Hills et al., 1992)

      Homozygous and rut2 dncM14 flies learn about half as well as wild-type controls. Hemizygous flies show essentially wild-type activation and inhibition of adenylate cyclase at various concentrations of calcium ions, although the basal level of adenylate cyclase activity is reduced.

      (Feany, 1990)

      recovered as partial suppressor of the female sterility of homozygous dnc females.

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Phenotype Manifest In
      NOT Suppressor of
      Statement
      Reference

      rut[+]/rut2 is a non-suppressor of nurse cell | increased number phenotype of dncM14/dnc221b

      (Swan et al., 2001)

      rut[+]/rut2 is a non-suppressor of nurse cell & nucleus phenotype of dncM14/dnc221b

      (Swan et al., 2001)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of DopEcRScer\UAS.cIb under the control of Scer\GAL4Mef2.247.Switch in adult mushroom body neurons (using RU486 to limit the timing of expression) restores courtship memory in a courtship conditioning assay in rut2 males.

      (Ishimoto et al., 2013)

      rut2 partially rescues the egg laying defects of dnc221b/dncM14, but fails to rescue the nurse cell nuclear morphology and 32-cell cyst defects.

      (Swan et al., 2001)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Gregory.

      Selected as: Suppressor of the sterility caused by dncM14.

      (Feany, 1990)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      BG2
      rut2
      (Sakurai et al., 2021, Ishimoto et al., 2013)
      Name Synonyms
      Secondary FlyBase IDs
        References (11)