FB2024_03 , released June 25, 2024
Allele: Dmel\Pu2
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General Information
Symbol
Dmel\Pu2
Species
D. melanogaster
Name
FlyBase ID
FBal0014004
Feature type
allele
Associated gene
Dmel\Pu
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
spontaneous
(Mackay et al., 1985)
Progenitor genotype
Cytology

Polytene chromosomes normal.

Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Shows reduction in profile of DOPA accumulation after adult eclosion.

      (Piedrafita et al., 1994)

      Cuticle defects.

      (Reynolds and O'Donnell, 1987)

      GTP cyclohydrolase activity is reduced to less than 50% of wild-type in the prepupa, adult body and adult head of heterozygotes.

      (Mackay et al., 1985)

      Eye colour: purplish, resembles pr1. Class II allele.

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments

      Non-complementing allele.

      Images (0)
      Mutant
      Wild-type
      Stocks (11)
      Notes on Origin
      Discoverer

      Grell, Feb. 1957.

      Grell.

      (O'Donnell, 1982)
      Comments
      Comments

      GTP CH activity reduced to less than 50% normal levels, in prepupae, adult body and adult head, i.e. lower than observed in deficiency heterozygotes. Activity 80% normal in genotypes that carry, in addition to Pu2, two doses of Pu+.

      Heterozygotes have 18% enzyme activity compared to wild-type, this reduction in activity being evident in all tissues and developmental times in which the enzyme is normally expressed. Levels of all pteridine compounds are diminished. Heterozygotes also carrying an inversion of the 57C-57D region of 2R which contains Pu have at least 80% enzyme activity compared to wild-type.

      (O'Donnell, 1982)

      The viability and eye phenotype in trans with other Pu alleles has been determined.

      (Mackay et al., 1985)

      Class II Pu allele.

      (Reynolds and O'Donnell, 1987)

      19 - 33% activity of the wild type enzyme. Diminished levels of 5,6,7,8-tetrahydroperin and 5,6,7,8-tetrahydrobioperin.

      (Guillamon and Ferre, 1988)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Pu2
      Name Synonyms
      Secondary FlyBase IDs
        References (10)