Amino acid replacement: G17S.
G1357485A
G17S | png-PA
G17S|FBrf0129806
site of nucleic acid difference inferred by FlyBase based on stated amino acid change
Unfertilised eggs from a homozygous mother initiate DNA replication inappropriately and have a single giant polyploid nuclei, fertilised eggs exhibit DNA replication that is partially uncoupled from nuclear division resulting in 6-16 giant polyploid nuclei. Trans-heterozygotes with the single nuclei alleles, png1, png3 and png5, produce embryos with multiple polyploid nuclei.
Embryonic defects detectable during preblastoderm stages.
Residual png activity permits a transient link of DNA replication to mitosis.