FB2024_03 , released June 25, 2024
Allele: Dmel\png158
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General Information
Symbol
Dmel\png158
Species
D. melanogaster
Name
FlyBase ID
FBal0013903
Feature type
allele
Associated gene
Dmel\png
Associated Insertion(s)
Carried in Construct
Also Known As
png12-158
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Lindsley and Zimm, 1992)
Progenitor genotype
Cytology
Description

Amino acid replacement: Q262term.

(Fenger et al., 2000)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:1,356,750..1,356,750 [-]
Nucleotide change:

C1356750T

Amino acid change:

Q262term | png-PA

Reported amino acid change:

Q262term

Comment:

site of nucleic acid difference inferred by FlyBase based on stated amino acid change

(Fenger et al., 2000)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Preblastoderm lethal.

      (Lindsley and Zimm, 1992)

      Homozygous mothers produce fertilised embryos, DNA replication is uncoupled from nuclear division resulting in one giant polyploid nuclei. Trans-heterozygotes with the multiple nuclei alleles, png2 and png4, produce embryos with multiple polyploid nuclei.

      (Shamanski and Orr-Weaver, 1991)

      Embryonic defects detectable during preblastoderm stages.

      (Mohler and Carroll, 1984)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      References (7)