FB2024_03 , released June 25, 2024
Allele: Dmel\ph-d504
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General Information
Symbol
Dmel\ph-d504
Species
D. melanogaster
Name
FlyBase ID
FBal0013758
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
ph504, ph0
Key Links
Nature of the Allele
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

Ovaries carrying germ-line clones homozygous for "ph0" (ph-d504 ph-p504) are normal. When somatic clones homozygous for "ph0" (ph-d504 ph-p504) are induced 4, 6 or 8 days after eclosion, they are rarely detected in the follicular epithelium of the ovary even though large wild-type twin-spots are frequently present. These mutant clones can occasionally be observed in the process of being 'expulsed' from the follicular epithelium. Despite this, ovaries containing these clones contain fused egg chambers and apposed egg chambers not separated by an interfollicular stalk. Where stalks are present they are sometimes abnormal - consisting of more than a dozen cells in 2-3 lines rather than five to seven cells organized in a single line as in wild-type. Only some of these abnormal stalks contain (surviving) mutant cells. Polar follicle cells are generally unaffected, although additional polar cells are very occasionally present in egg chambers of stage 5 or later. Small somatic clones of "ph0" (ph-d504 ph-p504) homozygous cells can be recovered in the germarium. In region 2b/3 of the germarium, these cells fail to extend long, thin cell processes centripetally as their wild-type counterparts do, but instead remain at the periphery with an abnormally rounded morphology.

Homozygous "ph0" (ph-d504 ph-p504) clones in the wing disc are large in size and rounded in shape and the imaginal disc cells are larger than wild type.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer

Associated with: ph-p504. The "ph504" chromosome carries mutations in both ph-d and ph-p.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
References (11)