FB2024_03 , released June 25, 2024
Allele: Dmel\otu8
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General Information
Symbol
Dmel\otu8
Species
D. melanogaster
Name
FlyBase ID
FBal0013355
Feature type
allele
Associated gene
Dmel\otu
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Storto and King, 1987, King et al., 1986)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      70% of homozygous ovarioles have quiescent oogonia, and 30% have tumorous oogonia. otu8/otu11 female flies are poorly fertile.

      (Storto and King, 1987)

      Quiescent allele; 70% of homozygous ovarioles contain vitellaria that lack developing follicles, 30% are tumour-generating. Hemizygous females do not produce tumour-generating ovarioles.

      (King et al., 1986)

      quiescent; ovarioles lack germ cells

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      otu8 is rescued by otu+t5.4

      (Comer et al., 1992)
      Comments

      Rescued by otu+t5.4 : fertility and normal ovarian development is restored.

      (Comer et al., 1992)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Engstrom.

      Comments
      Comments

      Quiescent (QUI) class allele. The ovarian phenotype of flies transheterozygous for otu8 and a number of other otu mutations has been analysed.

      (Storto and King, 1987)

      One of QUI class of alleles.

      (Comer et al., 1992)

      Shows a dominant interaction with ovoD2 and ovoD3 : more extreme mutant phenotype as assayed by reduction in number of egg chambers at stage 10 or further developed. There is no apparent correlation with strength of otu allele and its interaction with the ovo alleles. Reverse transcription and PCR, and in situ hybridization with the male specific exon, showed that the Sxl transcripts are spliced in the male-specific mode in transformed germ cells. This effect is alleviated by the SxlM1 mutation.

      (Pauli et al., 1993)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      1396
      (Mohler and Carroll, 1984)
      fs(1)1396
      fs1396
      (King et al., 1986)
      otu8
      Name Synonyms
      Secondary FlyBase IDs
        References (6)