FlyBase Allele Report: Dmel\nod[2]

General Information

Symbol

Dmel\nod²

Species

D. melanogaster

Name

FlyBase ID

FBal0013066

Feature type

allele

Associated gene

Dmel\nod

Associated Insertion(s)

3S18{}nod²

Carried in Construct

Also Known As

nod^b9

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

gamma ray

spontaneous

(Rasooly et al., 1994)

Progenitor genotype

Associated Insertion(s)

3S18{}nod²

Cytology

Polytene chromosomes normal.

(Zhang and Hawley, 1990)

Description

5.8kb insertion of a 3S18 element.

(Zhang et al., 1990)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal meiotic cell cycle | female (with nod^a)

(Apionishev et al., 2001)

abnormal meiotic cell cycle | recessive

(Zhang and Hawley, 1990)

Phenotype Manifest In

meiosis & nuclear chromosome | female (with nod^a)

(Apionishev et al., 2001)

Detailed Description

Statement

Reference

nod^a/FM7a nod² females show 43% X chromosome nondisjunction and 89% 4th chromosome nondisjunction.

(Apionishev et al., 2001)

High levels of X and fourth chromosome nondisjunction.

(Zhang and Hawley, 1990)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

nod² has abnormal meiotic cell cycle phenotype, enhanceable by neb[+]/neb^TE8

(Ruden et al., 1997)

nod² has abnormal meiotic cell cycle phenotype, enhanceable by neb[+]/neb^TE12

(Ruden et al., 1997)

nod² has abnormal meiotic cell cycle phenotype, enhanceable by neb[+]/neb^TE20

(Ruden et al., 1997)

Suppressed by

Statement

Reference

nod²/nod^a has abnormal meiotic cell cycle | female phenotype, suppressible by lwr⁰⁵⁴⁸⁶/lwr[+]

(Apionishev et al., 2001)

Enhancer of

Statement

Reference

nod[+]/nod² is an enhancer of abnormal meiotic cell cycle phenotype of neb^TE12

(Ruden et al., 1997)

nod[+]/nod² is an enhancer of abnormal meiotic cell cycle phenotype of neb^TE8

(Ruden et al., 1997)

nod[+]/nod² is an enhancer of abnormal meiotic cell cycle phenotype of neb^TE20

(Ruden et al., 1997)

Other

Statement

Reference

neb^TE2, nod² has female sterile | dominant phenotype

(Ruden et al., 1997)

Phenotype Manifest In

Enhanced by

Statement

Reference

nod² has phenotype, enhanceable by ncd¹

(Knowles and Hawley, 1991)

Suppressed by

Statement

Reference

nod²/nod^a has meiosis & nuclear chromosome | female phenotype, suppressible by lwr⁰⁵⁴⁸⁶/lwr[+]

(Apionishev et al., 2001)

Additional Comments

Genetic Interactions

Statement

Reference

nod^a/FM7a nod² female nondisjunction is dominantly suppressed by lwr⁰⁵⁴⁸⁶.

(Apionishev et al., 2001)

Ova from neb^TE8/+ (or neb^TE12/+ or neb^TE20/+) nod²/+ (or nod³/+ or nod⁴/+) transheterozygous females show a higher rate of 4th chromosome nondisjunction (up to 21%) than females heterozygous for either mutation alone. Transheterozygotes with neb^TE2 are sterile.

(Ruden et al., 1997)

ncd¹ nod² heterozygous females show an increased level of X and fourth chromosome nondisjunction.

(Knowles and Hawley, 1991)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

2331

FM7a, nod²/Dp(1;Y)y⁺/C(1)DX, y¹ f¹; sv^spa-pol

Kyoto

106771

FM7a, nod²/Dp(1;Y)y⁺/C(1)DX, y¹ f¹; sv^spa-pol

Notes on Origin

Discoverer

Induced on: In(1)FM7, y^31d sc⁸ w^a B v^Of.

External Crossreferences and Linkouts ( 2 )

Crossreferences

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

M94188

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

AAC14452

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

nod²

nod^b9

(Apionishev et al., 2001, Rasooly et al., 1994, Knowles and Hawley, 1991, Zhang and Hawley, 1990, Zhang et al., 1990)

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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