FB2024_03 , released June 25, 2024
Allele: Dmel\na1
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General Information
Symbol
Dmel\na1
Species
D. melanogaster
Name
FlyBase ID
FBal0012904
Feature type
allele
Associated gene
Dmel\na
Associated Insertion(s)
Carried in Construct
Also Known As
na
Key Links
Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Mir et al., 1997)
Mutagen
X ray
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mutants are noticeably smaller than wild-type but not obviously sick or deformed. The majority of homozygous mutants that have been entrained to diurnal lighting (LD, 12hr light:12hr dark) and subsequently monitored under constant darkness (DD) are arrhythmic - only a small number are strongly rhythmic. In contrast to wild-type however, under LD entrainment however mutants exhibit most activity at night. In the occasional rhythmic mutant flies the phase of activity during DD is similar to wild-type but in anti-phase compared to the same flies during LD.

      (Nash et al., 2002)

      Narrow abdomen, anaesthetic resistant and walking phenotypes of na1 are not complemented by nahar38. Response to enflurane and isoflurane is indistinguishable from wild type.

      (Mir et al., 1997)

      Homozygotes show resistance to halothane in an inebriometer assay (an assay of geotactic and postural behaviour) compared to wild-type flies.

      (Leibovitch et al., 1995)

      Abdomen long and cylindrical in both sexes. Viability low; female fertility low. Ovaries in juvenile condition (Brehme). RK2.

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      nahar38

      (Mir et al., 1997)

      nahar38

      (Leibovitch et al., 1995)
      Comments

      Narrow abdomen, anaesthetic resistant and walking phenotypes of na1 are not complemented by nahar38.

      (Mir et al., 1997)
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Alleles of na form a phenotypic series, going from strongest to weakest: nahar38 > nahar85 > naP890 > na1 > naPex1 > naPex2.

      (Mir et al., 1997)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Dmα1Una
      (Nash et al., 2002)
      na
      (Nash et al., 2002, Leibovitch et al., 1995)
      na1
      (Lam et al., 2018, Popodi et al., 2010-, Cook et al., 2009.11.25)
      Name Synonyms
      Secondary FlyBase IDs
        References (7)