FlyBase Allele Report: Dmel\mle[8]

General Information

Symbol

Dmel\mle⁸

Species

D. melanogaster

Name

FlyBase ID

FBal0012341

Feature type

allele

Associated gene

Dmel\mle

Associated Insertion(s)

Carried in Construct

Also Known As

mle^pm18, mle^pml8

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

gamma ray

ethyl methanesulfonate

(Kernan et al., 1991)

Progenitor genotype

Cytology

Description

Deletion of nucleotides 2366 to 2627. The deletion result in a frameshift leading to translation termination 4 codons later.

(Kuroda et al., 1991)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

2R:5,976,864..5,977,125 [-]

Comment:

262 base deletion

(Kuroda et al., 1991)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die before end of larval stage | male

(Bone et al., 1994)

some die during larval stage | male

(Bone et al., 1994)

Phenotype Manifest In

polytene chromosome

(Bhadra et al., 1999)

Detailed Description

Statement

Reference

The size of the 1A-5A region of the X chromosome and 21A-23F region of chromosome 2 of polytene chromosomes is significantly decreased in homozygous males compared to heterozygous controls.

(Bhadra et al., 1999)

Late third larval instar tissue from homozygous XY animals is poorly developed, appearing more like material from early third instar larvae.

(Meller et al., 1997)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Mutant phenotype can be rescued by P element mediated transformation of a wild type mle gene copy.

(Kernan et al., 1991)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

mle⁸ modulates P{Adh.Wa-F} and P{wB} at various locations, but affects the same construct differently depending on an X or autosomal location.

(Bhadra et al., 1999)

H4Ac16, acetylated form of His4, is not localised to the X chromosome in male salivary gland nuclei.

(Bone et al., 1994)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

mle⁸

mle^pm18

(Pal Bhadra et al., 2005, Lyman et al., 1997, Meller et al., 1997, Meller et al., 1996, Gorman et al., 1995, Palmer et al., 1994, Kernan et al., 1991)

mle^pml8

(Deng and Meller, 2006, Bhadra et al., 2000, Bhadra et al., 1999, Bone et al., 1994, Kuroda et al., 1991)

Name Synonyms

Secondary FlyBase IDs

References (13)

Report Sections

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