FB2024_03 , released June 25, 2024
Allele: Dmel\mgr1
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General Information
Symbol
Dmel\mgr1
Species
D. melanogaster
Name
FlyBase ID
FBal0012235
Feature type
allele
Associated gene
Dmel\mgr
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Ripoll et al., 1987)
Mutagen
X ray
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Larval neuroblasts show a variety of mutant phenotypes (monopolar anaphases resulting from failure in the centrosome cycle), during meiosis all cells present the same phenotype.

      (Ripoll et al., 1987)

      Most characteristic abnormality is appearance of mitotic and meiotic figures in which all the chromosomes are arranged in a circle. Other mutant traits include metaphase arrest, polyploid cells, postmeiotic cysts with 16 nuclei and spermatids carrying four times the normal complement of chromosomes. The circular mitotic figures (CMF's) are caused by monopolar spindles. The wild-type allele of mgr apparently is necessary for correct centrosome behavior.

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      mgrl4/mgr1 is rescued by Scer\GAL4Act.PU/mgrUAS.cDa

      (Delgehyr et al., 2012)
      Comments

      The pharate lethality associated with mgrl4/mgr1 can be rescued by Scer\GAL4Act.PU-mediated expression of mgrScer\UAS.cDa.

      (Delgehyr et al., 2012)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      mgr1
      (Palumbo et al., 2015, Delgehyr et al., 2012)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)