Amino acid replacement: R697Q. Nucleotide substitution: G2407A.
G4315519A
G2407A
R740Q | mei-9-PA; R740Q | mei-9-PB
Position of mutation on reference sequence inferred by FlyBase curator.
mei-9D4/mei-9A2 females show 24% X chromosome nondisjunction, compared to 0.33% in wild-type females. mei-9RT1/mei-9D4 females show a severe decrease in the level of crossing over along the left arm of chromosome 2 compared to wild type. mei-9D4/mei-9A2 larvae are hypersensitive to ultraviolet light and show intermediate sensitivity to nitrogen mustard.
mutagen sensitive reduces exchange
An endonuclease activity which is specific for partially depurinated DNA is reduced in extracts of mei-9D4 larval brain ganglia compared to wild-type.