FB2024_03 , released June 25, 2024
Allele: Dmel\mei-9D2
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General Information
Symbol
Dmel\mei-9D2
Species
D. melanogaster
Name
FlyBase ID
FBal0012177
Feature type
allele
Associated gene
Dmel\mei-9
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Mason et al., 1981)
Progenitor genotype
Cytology
Description

Deletion of nucleotides 553-558, resulting in an in frame deletion of two conserved residues (V143 and K144) at the beginning of helicase-like motif III.

(Yildiz et al., 2004)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      mei-9D2/mei-9A2 females show 29% X chromosome nondisjunction, compared to 0.33% in wild-type females. mei-9D2/mei-9A2 larvae are hypersensitive to ultraviolet light and nitrogen mustard.

      (Yildiz et al., 2004)

      Flies are sensitive to X rays.

      (Oliveri et al., 1990)

      Hemizygous male larvae are sensitive to HN2 and MMS. Homozygous females produce diplo-X and nullo-X exceptions at roughly the same frequency.

      (Mason et al., 1981)

      mutagen sensitive reduces exchange

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      The lesion in mei-9D2 and in mei-9D3 is identical.

      (Yildiz et al., 2004)
      Comments
      Comments

      Homozygotes have normal postreplication repair capabilities, but excision repair is reduced to undetectable levels. Homozygous cultured cells respond to UV irradiation with normal reductions in thymidine incorporation and with the synthesis of normal-length nascent DNA.

      (Brown and Boyd, 1981)

      An endonuclease activity which is specific for partially depurinated DNA is reduced in extracts of mei-9D2 larval brain ganglia compared to wild-type.

      (Osgood and Boyd, 1982)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      mei-9D2
      Name Synonyms
      Secondary FlyBase IDs
        References (7)