FB2024_03 , released June 25, 2024
Allele: Dmel\mam9
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General Information
Symbol
Dmel\mam9
Species
D. melanogaster
Name
FlyBase ID
FBal0012017
Feature type
allele
Associated gene
Dmel\mam
Associated Insertion(s)
Carried in Construct
Also Known As
mamIL42
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Tearle and Nusslein-Volhard, 1987)
Progenitor genotype
Cytology
Description

Amino acid replacement: Q1038term.

(Yedvobnick et al., 2004)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:14,056,539..14,056,539 [+]
Nucleotide change:

C14056539T

Amino acid change:

Q1159term | mam-PA; Q1159term | mam-PB; Q1159term | mam-PD

Reported amino acid change:

Q1038term

Comment:

Position of mutation on reference sequence inferred by FlyBase curator.

(Yedvobnick et al., 2004)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mutant embryos have a strong loss of asymmetry phenotype with GMC-1 of the RP2/sib lineage dividing symmetrically into two RP2 neurons in as many as 80% of hemisegments, resulting in a duplication of RP2 neurons.

      (Yedvobnick et al., 2004)

      Embryonic CNS exhibits severe disturbances and larval exhibit weak cuticle loss.

      (Schmid et al., 1996)

      Weak embryonic neurogenic phenotype.

      (Lehmann et al., 1983)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Both the daughter cells of the GMC-1 of the RP2/sib lineage adopt an RP2 fate in mam9 numb796 double mutant embryos, indicating that mam is epistatic to numb.

      (Yedvobnick et al., 2004)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Complements

      mam44

      (Yedvobnick et al., 2004)
      Not rescued by

      mam9 is not rescued by Scer\GAL4hs.PH/mamN.UAS

      (Yedvobnick et al., 2004)
      Comments

      The loss of asymmetric division in GMC-1 of the RP2/sib lineage and the neurogenic phenotype seen in mam9 embryos is not rescued by expression of mamN.Scer\UAS under the control of Scer\GAL4hs.PH between 6 and 8 hours of development. mam44 and mam9 show interallelic complementation; there is a significant rescue of the loss of asymmetric division in GMC-1 of the RP2/sib lineage, so that most hemisegments show normal specification of the RP2sib neuron in transheterozygotes.

      (Yedvobnick et al., 2004)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      mam9
      mamIL42
      (Yedvobnick et al., 2004, Schmid et al., 1996, Lehmann et al., 1983)
      mamIL42R
      (Yedvobnick et al., 2004)
      mamIL4
      (Tearle and Nusslein-Volhard, 1987)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)