FlyBase Allele Report: Dmel\pan[13a]

General Information

Symbol

Dmel\pan^13a

Species

D. melanogaster

Name

FlyBase ID

FBal0011367

Feature type

allele

Associated gene

Dmel\pan

Associated Insertion(s)

Carried in Construct

Also Known As

l(4)13

Key Links

Genomic Maps

JBrowse

Allele class

hypomorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(van de Wetering et al., 1997)

Mutagen

ethyl methanesulfonate

(Hochman, 1976, Hochman, 1974, Hochman, 1971)

Progenitor genotype

Cytology

Description

Amino acid replacement: A374V. Mutation in the third homology domain.

(van de Wetering et al., 1997)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

4:99,430..99,430 [+]

Nucleotide change:

C99430T

Amino acid change:

Reported amino acid change:

A374V

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(van de Wetering et al., 1997)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

embryonic/first instar larval cuticle | ventral

(Slusarski et al., 1995)

segment

(van de Wetering et al., 1997)

Detailed Description

Statement

Reference

Regions of naked cuticle are replaced by cuticle with denticles.

(van de Wetering et al., 1997)

Deletion of ventral naked cuticle in embryos. Complements the segmentation defects of ci^Ce-r1 and the wing vein defects of ci¹.

(Slusarski et al., 1995)

Segment polarity phenotype.

(Eaton and Kornberg, 1990)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

pan[+]/pan^13a is a suppressor of abnormal size phenotype of Scer\GAL4^GMR.PF, egr^UAS.cIa

(Zhang et al., 2015)

pan[+]/pan^13a is a suppressor of visible phenotype of Scer\GAL4^GMR.PF, egr^UAS.cIa

(Zhang et al., 2015)

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

pan^13a is a non-enhancer of wing phenotype of Scer\GAL4^bbg-C96, mam^N.UAS

(Helms et al., 1999)

Suppressor of

Statement

Reference

pan[+]/pan^13a is a suppressor of eye phenotype of Scer\GAL4^GMR.PF, egr^UAS.cIa

(Zhang et al., 2015)

NOT Suppressor of

Statement

Reference

pan^13a is a non-suppressor of wing phenotype of Scer\GAL4^bbg-C96, mam^N.UAS

(Helms et al., 1999)

Additional Comments

Genetic Interactions

Statement

Reference

Has no effect on the wing nicking phenotype seen in mam^N.Scer\UAS, Scer\GAL4^C96 flies.

(Helms et al., 1999)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

pan^13a is rescued by pan^hs.PW

(van de Wetering et al., 1997)

Comments

Lethality can be rescued by heat induced expression of pan^hs.PW.

(van de Wetering et al., 1997)

Images (0)

Mutant

Wild-type

Stocks (1)

Kyoto

107565

pan^13a/Dp(2;4)ey^D, Ablp^eyD: ey^D

Notes on Origin

Discoverer

Comments

pan and ci loci display a complex complementation pattern: pan fails to complement lethal alleles of ci but complements ci^Ce-r1 and viable ci alleles.

(Locke and Tartof, 1994)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (8)

Reported As

Symbol Synonym

(Hochman, 1971)

ci^102ABb-1

ci^l(4)13

(Slusarski et al., 1995)

dTCF¹

(van de Wetering et al., 1997)

l(4)102ABb

l(4)13

(Locke and Tartof, 1994, Eaton and Kornberg, 1990, Hochman, 1976, Hochman, 1974)

l(4)13a

(van de Wetering et al., 1997)

pan^13a

(Zhang et al., 2015)

Name Synonyms

Secondary FlyBase IDs

References (10)

Report Sections

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