FB2024_03 , released June 25, 2024
Allele: Dmel\l(1)dd111
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General Information
Symbol
Dmel\l(1)dd111
Species
D. melanogaster
Name
FlyBase ID
FBal0007451
Feature type
allele
Associated gene
l(1)dd11
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
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        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Imaginal discs of homozygous larvae are missing or degenerate. Defects in the cell cycle: few or no dividing cells, arrest of the cell cycle at metaphase and cell division failures that result in highly polyploid cells.

        (Gatti and Baker, 1989)

        Discs missing or degenerate; mitotic index of larval ganglion cells and chromosome condensation normal; 43.5% of metaphases polyploid; cells containing 500 to 1000 chromosomes encountered; some chromosome fragmentation seen (Gatti and Baker, 1989). Homozygous cells in ovary lethal (Perrimon, Engstrom, and Mahowald, 1984). late pupal lethal mitotic phenotype: highly polyploid cells, many anaphases, some multipolar

        External Data
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        Phenotypic Class
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        Additional Comments
        Genetic Interactions
        Statement
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        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        Comments
        Comments

        Maternal germline clonal analysis demonstrates cell lethality in homozygous clones.

        (Perrimon et al., 1989)
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        d-deg11
        (Perrimon et al., 1989)
        l(1)dd111
        Name Synonyms
        Secondary FlyBase IDs
          References (2)