FB2024_03 , released June 25, 2024
Allele: Dmel\hry49
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General Information
Symbol
Dmel\hry49
Species
D. melanogaster
Name
FlyBase ID
FBal0005366
Feature type
allele
Associated gene
Dmel\hry
Associated Insertion(s)
Carried in Construct
Also Known As
hm3
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
X ray
(Hooper et al., 1989, Ingham et al., 1985)
Progenitor genotype
Caused by aberration
Tp(3;3)hryM3
Cytology
Description

Previous localization of breakpoint refined to approximately 9.5--10.75kb upstream of h.

(Lardelli and Ish-Horowicz, 1993)

Deletion of upstream regulatory sequences of h, leaving approximately 11kb of upstream sequences intact.

(Howard and Struhl, 1990)

Rearrangement of chromosome upstream of the h promoter. Approximately 10kb of upstream sequences remain intact.

(Hooper et al., 1989)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Second thoracic and third abdominal segment is absent in the embryo. T2/A1 and A1/A3 fusions also occur.

      (Lardelli and Ish-Horowicz, 1993)

      Cuticle defects between T1 and A2.

      (Hooper et al., 1989)

      Class II allele: shows a strong bristle phenotype in trans with h1, and a weak segmentation phenotype either when homozygous or in trans with h25.

      (Ingham et al., 1985)

      Regulatory mutation causing alterations in hairy expression in cellular blastoderm that result in a partial version of the wild-type pattern (Howard, Ingham and Rushlow, 1988).

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      Ingham.

      Comments
      Comments

      Selected on the basis of its failure to complement the bristle phenotype of either h1 or h2. The h49 mutation has a maternal effect on h49 mutant zygotes.

      (Ingham et al., 1985)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      h49
      hm3
      (Yu and Pick, 1995, Lardelli and Ish-Horowicz, 1993, Howard and Struhl, 1990, Hooper et al., 1989, Howard, 1988, Ingham et al., 1985)
      hry49
      Name Synonyms
      Secondary FlyBase IDs
        References (7)