FB2024_03 , released June 25, 2024
Allele: Dmel\hry42
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General Information
Symbol
Dmel\hry42
Species
D. melanogaster
Name
FlyBase ID
FBal0005359
Feature type
allele
Associated gene
Dmel\hry
Associated Insertion(s)
Carried in Construct
Also Known As
hK1
Key Links
Allele class

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Howard and Ingham, 1986)
Mutagen
X ray
(Hooper et al., 1989, Ingham et al., 1985)
Progenitor genotype
Caused by aberration
In(3L)hry42
Cytology
Description

Previous localization of breakpoint refined to approximately 3kb upstream of h.

(Lardelli and Ish-Horowicz, 1993)

Inversion break falls approximately 2.5kb 5' to the start of transcription (Ingham et al., Genetics 111: 463--486, Howard et al., Genes Dev. 2: 1037--1046.)

(Orenic et al., 1993)

Deletion of upstream regulatory sequences of h, leaving approximately 5.5kb of upstream sequences intact.

(Howard and Struhl, 1990)

Rearrangement of chromosome upstream of the h promoter. Approximately 3kb of upstream sequences remain intact.

(Hooper et al., 1989)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Cuticle defects.

      (Hooper et al., 1989)

      Even numbered denticle bands missing.

      (Jack et al., 1988)

      "Pair-rule segmentation phenotype": half the normal number of denticle bands form, due to a deletion of pattern elements from approximately the middle of one segment to a homologous position in the next segment.

      (Howard and Ingham, 1986)

      Class IV allele: has a strong segmentation phenotype either when homozygous or in trans with h25, and fails to complement the bristle phenotype of h1.

      (Ingham et al., 1985)

      Regulatory mutation causing alterations in hairy expression in cellular blastoderm that result in a partial version of the wild-type pattern (Howard, Ingham and Rushlow, 1988). viable

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Ingham.

      Comments
      Comments

      Selected on the basis of its failure to complement the bristle phenotype of either h1 or h2.

      (Ingham et al., 1985)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      References (15)