FB2024_03 , released June 25, 2024
Allele: Dmel\hry27
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General Information
Symbol
Dmel\hry27
Species
D. melanogaster
Name
FlyBase ID
FBal0005344
Feature type
allele
Associated gene
Dmel\hry
Associated Insertion(s)
Carried in Construct
Also Known As
h8K115
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Wainwright and Ish-Horowicz, 1992, Hooper et al., 1989, Tearle and Nusslein-Volhard, 1987, Ingham et al., 1985)
Progenitor genotype
Cytology

Polytene chromosomes normal.

(Ingham et al., 1985)
Description

Deletion of DNA, producing a truncated h protein that is deleted from amino acid Q300 onwards.

(Wainwright and Ish-Horowicz, 1992)

Deletion of approximately 250bp, that includes the carboxy-terminal protein encoding region of h.

(Hooper et al., 1989)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
delins
3L:8,678,307..8,678,544 [+]
Comment:

A 238bp deletion/3bp insertion which removes 117bp of coding sequence and 121bp of adjacent 3' UTR. The deletion removes the last 38 amino acids of the h protein and includes one extra amino acid from the 3bp insertion. Translation terminates just after the insertion.

Inserted_sequence:

ATT

(Wainwright and Ish-Horowicz, 1992)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Strong pair-rule cuticular phenotype.

      (Hooper et al., 1989)

      Transheterozygotes with hL43a are lethal, strong pair-rule phenotype.

      (Fasano et al., 1988)

      Homozygous clones in the wing produce extra bristles. Class IV allele: has a strong segmentation phenotype either when homozygous or in trans with h25, and fails to complement the bristle phenotype of h1.

      (Ingham et al., 1985)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Jurgens.

      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      h27
      h8K115
      (Hooper et al., 1989, Fasano et al., 1988, Ingham et al., 1985)
      h8K
      (Wainwright and Ish-Horowicz, 1992, Tearle and Nusslein-Volhard, 1987)
      hry27
      Name Synonyms
      Secondary FlyBase IDs
        References (6)