FlyBase Allele Report: Dmel\fz[13]

General Information

Symbol

Dmel\fz¹³

Species

D. melanogaster

Name

FlyBase ID

FBal0004929

Feature type

allele

Associated gene

Dmel\fz

Associated Insertion(s)

Carried in Construct

Also Known As

fz^F31

Key Links

Genomic Maps

JBrowse

Allele class

neomorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

neomorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

(Adler et al., 1990)

Progenitor genotype

Cytology

Description

Amino acid replacement: P278S.

(Povelones et al., 2005, Jones et al., 1996)

Mutation is in the first cytoplasmic loop of the fz protein.

(Jones et al., 1996)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3L:14,311,900..14,311,900 [+]

Nucleotide change:

C14311900T

Reported nucleotide change:

C?T

Amino acid change:

P278S | fz-PA; P278S | fz-PC

Reported amino acid change:

P278S

Comment:

P278 is in the first cytoplasmic loop of the fz protein.

(Povelones et al., 2005, Jones et al., 1996)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible (with fz³⁰)

(Povelones et al., 2005)

Phenotype Manifest In

wing

(Jones et al., 1996)

wing hair | increased number (with fz³⁰)

(Povelones et al., 2005)

Detailed Description

Statement

Reference

fz¹³ has a weak multiple wing hair phenotype in combination with fz³⁰.

(Povelones et al., 2005)

Autonomous phenotype in wing clones.

(Jones et al., 1996)

eye texture normal causes severe disruption of trichome orientation in the costal wing cell, a region little affected by most alleles; phenotype of homozygote more severe than that of hemizygote. Also unlike other alleles, homozygous clones of fz¹³ cells in the wing do not affect orientation of trichomes in surrounding normal cells. A third notable feature of fz¹³ is that it is without effect on eye texture. moderate thoracic bristle phenotype moderate wing-hair disorientation

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

fz[+]/fz¹³ is a suppressor of abnormal planar polarity phenotype of Scer\GAL4^hs.2sev, dgo^UAS.cFa

(Jenny et al., 2005)

Phenotype Manifest In

Suppressor of

Statement

Reference

fz[+]/fz¹³ is a suppressor of ommatidium phenotype of Scer\GAL4^hs.2sev, dgo^UAS.cFa

(Jenny et al., 2005)

Additional Comments

Genetic Interactions

Statement

Reference

The planar cell polarity defects seen in the eyes of flies expressing dgo^Scer\UAS.cFa under the control of Scer\GAL4^hs.2sev are dominantly suppressed by fz¹³/+.

(Jenny et al., 2005)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Adler.

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

(Weber et al., 2012)

F31

(Weber et al., 2012)

Fz^F31

(Nye et al., 2020)

fz¹³

fz^F31

(Weiner et al., 2020, Amonlirdviman et al., 2005, Jenny et al., 2005, Povelones et al., 2005, Jones et al., 1996, Adler et al., 1990)

Name Synonyms

Secondary FlyBase IDs

References (10)

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