FlyBase Allele Report: Dmel\fs(1)K10[1]

General Information

Symbol

Dmel\fs(1)K10¹

Species

D. melanogaster

Name

FlyBase ID

FBal0004297

Feature type

allele

Associated gene

Dmel\fs(1)K10

Associated Insertion(s)

Carried in Construct

Also Known As

fs(1)K10

Key Links

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Haenlin et al., 1995, Forlani et al., 1993)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Mutant females produce outwardly dorsalised eggs.

(Sen et al., 2000)

Eggs laid by fs(1)K10¹ mothers are dorsalised. Dorsal appendage material expands to form a collar surrounding the ventral side of the egg. The dorsal gap between the pair of dorsal appendages remains but shifts ventrally.

(Zhao and Bownes, 1999)

Females produce eggs with ventrally fused dorsal appendages.

(Deng and Bownes, 1997)

A ring of dorsal appendage material encircles the anterior end of the eggshell in fs(1)K10¹ eggs.

(Dobens et al., 1997)

Mothers lay dorsalised eggs, the dorsal appendages form a collar around the entire circumference of the egg.

(Gonzalez-Reyes et al., 1997)

Dorsalised egg chambers.

(Hsu et al., 1996)

Homozygous females lay dorsalised eggs that develop into dorsalised embryos if fertilised.

(Schnorr and Berg, 1996)

Embryos exhibit a dorsalised phenotype.

(Gonzalez-Reyes et al., 1995)

Eggs produced by fs(1)K10¹ grk^ED22 double mutant females are more ventralised than eggs produced by grk^ED22 single mutant females. Most double mutant eggs contain no or only a node of dorsal appendage material positioned on the dorsal midline, whereas grk^ED22 single mutant eggs have at least one dorsal appendage that usually extends anteriorly beyond the anterior tip of the egg.

(Serano et al., 1995)

Homozygous females lay dorsalised embryos, dorsal appendages are fused in a ring at the anterior end and eggs are smaller and more spherical than wild type.

(Brand and Perrimon, 1994)

Eggs laid by homozygous females are dorsalised and develop into dorsalised embryos. Females double mutant for fs(1)K10¹ and Dsor1^ts1 lay eggs with fused dorsal appendages at 18^oC, at 29^oC the dorsalised eggshell phenotype is strongly suppressed to varying degrees, some eggs are fertilised.

(Hsu and Perrimon, 1994)

Egg shells strongly dorsalized with 84% of eggs having ventrally fused dorsal appendages. Less than 1% of eggs contain embryos, which have reduced or no filzkorper, and show an expansion of ventral epidermis posteriorly.

(Roth and Schupbach, 1994)

Weak allele. Homozygous females lay eggs with a partially dorsalised chorion. The phenotype is stronger anteriorly, as the most posterior segments of the embryos produced have narrow ventral denticle belts. The phenotype is enhanced, resulting in the loss of ventral structures posteriorly, in embryos derived from hemizygous females. 2-5% of the eggs laid by homozygous females are fertilised. fs(1)K10¹ heterozygous or homozygous females also homozygous for grk³, grk⁶ or Egfr^t1 produce eggs with a ventralised phenotype. fs(1)K10¹ homozygous females also heterozygous for Egfr^t1 produce eggs with a dorsalised phenotype.

(Forlani et al., 1993)

Embryos from double mutants with sqd^ix43 are strongly dorsalised.

(Kelley, 1993)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressed by

Statement

Reference

fs(1)K10¹ has egg chamber phenotype, suppressible by Cf2^s.hs

(Hsu et al., 1996)

Additional Comments

Genetic Interactions

Statement

Reference

When pip^hs.PS is expressed in fs(1)K10¹ females, ventralised embryos carrying ventral denticle material are produced inside dorsalised egg shells.

(Sen et al., 2000)

Double mutants with spn-B¹, mus301⁴²² or spn-D² display an indistinguishable phenotype from fs(1)K10¹ single mutants.

(Gonzalez-Reyes et al., 1997)

Overexpression of Cf2^s.hs can reduce the dorsalising effects, 10% of eggs display two distinct dorsal appendages. Overexpression during oogenesis similarly rescues the maternal dorsalising effect so 12% of embryos have restored ventral denticles.

(Hsu et al., 1996)

fs(1)K10¹; Egfr^top-18A or fs(1)K10¹; grk³ double mutant females produce eggs with ventralised eggshells and embryos. fs(1)K10¹/fs(1)K10¹; Ras85D^ix13b/Ras85D^e2F females lay eggs that range from strongly dorsalised to weakly ventralised, indistinguishable from Ras85D mutant eggs. The embryos range from strongly dorsalised to weakly dorsalised, to almost normal with slight head defects.

(Schnorr and Berg, 1996)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Kyoto

101905

fs(1)K10¹ w¹ / ClB / Dp(1;Y)Bar^S ; mwh¹ se¹ e¹

Notes on Origin

Discoverer

Wieschaus, Marsh and Gehring (1978).

Comments

Mutation does not affect posterior follicle cell determination.

(Gonzalez-Reyes et al., 1995)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

K10¹

(Gonzalez-Reyes et al., 1997)

fs(1)K10

(Jaramillo et al., 2008, Lin et al., 2007, Reich et al., 1999, Zhao and Bownes, 1999, Dobens et al., 1997, Schnorr and Berg, 1996, Neuman-Silberberg and Schupbach, 1993)

fs(1)K10¹

(Handke et al., 2014, Andreu et al., 2012, Andrenacci et al., 2000)

Name Synonyms

Secondary FlyBase IDs

References (30)

Report Sections

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