FB2024_03 , released June 25, 2024
Allele: Dmel\fkh1
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General Information
Symbol
Dmel\fkh1
Species
D. melanogaster
Name
FlyBase ID
FBal0004007
Feature type
allele
Associated gene
Dmel\fkh
Associated Insertion(s)
Carried in Construct
Also Known As
fkhE200
Key Links
Genomic Maps

Allele class

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Casanova, 1990, Weigel et al., 1989)
Mutagen
ethyl methanesulfonate
(Weigel et al., 1989, Tearle and Nusslein-Volhard, 1987)
Progenitor genotype
Cytology
Description

Amino acid replacement: W254term.

(Weigel et al., 1989)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:28,583,792..28,583,792 [-]
Nucleotide change:

G28583792A

Reported nucleotide change:

G?A

Amino acid change:

W254term | fkh-PA; W254term | fkh-PB; W254term | fkh-PC; W254term | fkh-PD; W254term | fkh-PE

Reported amino acid change:

W254term

Comment:

TGG to TGA

(Weigel et al., 1989)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      During embryogenesis the salivary secretory cells fail to invaginate and eventually disappear. Salivary duct cells also fail to invaginate to form tubes but do occasionally invaginate to form a teardrop-shaped structure.

      (Isaac and Andrew, 1996)

      Most of the gut epithelium degenerates during stages 12/13, generating a high level of cell death. All interior hemocytes become macrophages at an early stage. Hemocytes are attracted to the region of cell death from more superficial levels.

      (Tepass et al., 1994)

      Defective in gonad assembly.

      (Warrior, 1994)

      Failure of head involution. Homeotic transformations in the pre-oral head region and the foregut. Posterior tail region and the hindgut are homeotically replaced by anterior tail and post-oral head. Embryos lack oesophagus, proventriculus, hindgut and Malpighian tubules.

      (Jurgens and Weigel, 1988)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The body weight of TorΔP/+ flies is increased by the presence of fkh1/+.

      (Bülow et al., 2010)

      Anterior-posterior polarization of cells in the extending germband is disrupted in kni10 hb4 fkh1 tll1 homozygous embryos.

      (Zallen and Wieschaus, 2004)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      fkh1
      (Bülow et al., 2010)
      fkhE200-17
      (Edgar et al., 1994)
      fkhE200
      (Zallen and Wieschaus, 2004, Moore et al., 1998, Irvine and Wieschaus, 1994, Tearle and Nusslein-Volhard, 1987)
      Name Synonyms
      Secondary FlyBase IDs
        References (16)