FB2024_03 , released June 25, 2024
Allele: Dmel\esc9
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General Information
Symbol
Dmel\esc9
Species
D. melanogaster
Name
FlyBase ID
FBal0003829
Feature type
allele
Associated gene
Dmel\esc
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - genetic evidence

Mutagen
    Nature of the Allele
    Allele class

    amorphic allele - genetic evidence

    Mutagen
    Progenitor genotype
    Cytology
    Description

    Amino acid replacement: M236K. M236K falls in the WD4 domain.

    (Tie et al., 1998)

    Amino acid replacement: M236K. Nucleotide substitution: T?A. Residue immediately precedes the highly conserved Asp237 in the middle of WD3.

    (Sathe and Harte, 1995)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    point_mutation
    2L:11,828,031..11,828,031 [-]
    Nucleotide change:

    T11828031A

    Reported nucleotide change:

    T?A

    Amino acid change:

    M236K | esc-PA

    Reported amino acid change:

    M236K

    (Sathe and Harte, 1995)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Suppressor of
        Statement
        Reference

        esc9/esc[+] is a suppressor of visible | dominant | homeotic phenotype of brm[+]/brm2, trxE2

        (Gildea et al., 2000)

        esc9/esc[+] is a suppressor of visible | dominant | homeotic phenotype of ash117, trxB11/trx[+]

        (Gildea et al., 2000)
        Phenotype Manifest In
        Suppressor of
        Statement
        Reference

        esc9/esc[+] is a suppressor of adult metathoracic segment phenotype of brm[+]/brm2, trxE2

        (Gildea et al., 2000)

        esc9/esc[+] is a suppressor of adult metathoracic segment phenotype of ash117, trxB11/trx[+]

        (Gildea et al., 2000)
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer

        Struhl.

        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        esc9
        Name Synonyms
        Secondary FlyBase IDs
          References (4)